Hossain, MF, Gong, RH and Rigout, M (2015) Preparation and characterization of poly(ethylene oxide)-loaded hydroxypropyl-β-cyclodextrin nanofibers. Polymers for Advanced Technologies, 26 (9). 1184 - 1188. ISSN 1042-7147
Abstract
Hydroxypropyl-β-cyclodextrin (HP-β-CD) is a modified β-cyclodextrin (β-CD) derivative, which is toxicologically harmless to mammals and other animals. HP-β-CD is electrospun from an aqueous solution by blending with a non-toxic, biocompatible, synthetic polymer poly(ethylene oxide) (PEO). Aqueous solutions containing different HP-β-CD/PEO blends (50:50–80:20) with variable concentrations (4 wt%–12 wt%) were used. Scanning electron microscope was used to investigate the morphology of the fibers, and Fourier transform infrared spectroscopy analysis confirmed the presence of HP-β-CD in the fiber. Uniform nanofibers with an average diameter of 264, 244, and 236 nm were obtained from 8 wt% solution of 50:50, 60:40, and 70:30 HP-β-CD/PEO, respectively. The average diameter of the fiber was decreased with increasing of HP-β-CD/PEO ratio. However, a higher proportion of HP-β-CD in the spinning solution increased beads in the fibers. The polymer concentration had no significant effect on the fiber diameter. The most uniform fibers with the narrowest diameter distribution were obtained from the 8 wt% of 50:50 solution.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, John Wiley & Sons, Ltd. This is the peer reviewed version of the following article: Hossain, MF, Gong, RH and Rigout, M (2015) Preparation and characterization of poly(ethylene oxide)-loaded hydroxypropyl-β-cyclodextrin nanofibers. Polymers for Advanced Technologies, 26 (9). 1184 - 1188. ISSN 1042-7147, which has been published in final form at http://dx.doi.org/10.1002/pat.3552. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | electrospinning; hydroxypropyl-β-cyclodextrin; poly(ethylene oxide) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 Nov 2015 11:47 |
Last Modified: | 23 Nov 2016 15:18 |
Published Version: | http://dx.doi.org/10.1002/pat.3552 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/pat.3552 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:91913 |