Bou-Francis, A, López, A, Persson, C et al. (2 more authors) (2014) Assessing cement injection behaviour in cancellous bone: an in vitro study using flow models. Journal of Biomaterials Applications, 29 (4). pp. 582-594. ISSN 0885-3282
Abstract
Understanding the cement injection behaviour during vertebroplasty and accurately predicting the cement placement within the vertebral body is extremely challenging. As there is no standardized methodology, we propose a novel method using reproducible and pathologically representative flow models to study the influence of cement properties on injection behaviour. The models, confined between an upper glass window and a lower aluminium plate, were filled with bone marrow substitute and then injected (4, 6 and 8 min after cement mixing) with commercially available bone cements (SimplexP, Opacity+, OsteopalV and Parallax) at a constant flow rate (3 mL/min). A load cell was used to measure the force applied on the syringe plunger and calculate the peak pressure. A camera was used to monitor the cement flow during injection and calculate the following parameters when the cement had reached the boundary of the models: the time to reach the boundary, the filled area and the roundness. The peak pressure was comparable to that reported during clinical vertebroplasty and showed a similar increase with injection time. The study highlighted the influence of cement formulations and model structure on the injection behaviour and showed that cements with similar composition/particle size had similar flow behaviour, while the introduction of defects reduced the time to reach the boundary, the filled area and the roundness. The proposed method provides a novel tool for quick, robust differentiation between various cement formulations through the visualization and quantitative analysis of the cement spreading at various time intervals.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) The Authors, 2014. This is an author produced version of a paper published in the Journal of Biomaterials Applications. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bone cement; bone surrogates; cement flow behaviour; cement leakage; vertebral augmentation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Apr 2016 12:48 |
Last Modified: | 18 Jan 2018 07:07 |
Published Version: | http://dx.doi.org/10.1177/0885328214537858 |
Status: | Published |
Publisher: | SAGE Publications |
Identification Number: | 10.1177/0885328214537858 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:91079 |