Burns, Michael J orcid.org/0000-0002-5569-1270, Rayner, Peter J orcid.org/0000-0002-6577-4117, Green, Gary G R orcid.org/0000-0003-1977-7509 et al. (3 more authors) (2015) Improving the hyperpolarization of (31)p nuclei by synthetic design. Journal of Physical Chemistry B. pp. 5020-5027. ISSN 1520-5207
Abstract
Traditional (31)P NMR or MRI measurements suffer from low sensitivity relative to (1)H detection and consequently require longer scan times. We show here that hyperpolarization of (31)P nuclei through reversible interactions with parahydrogen can deliver substantial signal enhancements in a range of regioisomeric phosphonate esters containing a heteroaromatic motif which were synthesized in order to identify the optimum molecular scaffold for polarization transfer. A 3588-fold (31)P signal enhancement (2.34% polarization) was returned for a partially deuterated pyridyl substituted phosphonate ester. This hyperpolarization level is sufficient to allow single scan (31)P MR images of a phantom to be recorded at a 9.4 T observation field in seconds that have signal-to-noise ratios of up to 94.4 when the analyte concentration is 10 mM. In contrast, a 12 h 2048 scan measurement under standard conditions yields a signal-to-noise ratio of just 11.4. (31)P-hyperpolarized images are also reported from a 7 T preclinical scanner.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Copyright © 2015 American Chemical Society. This is an author produced version of a paper published in Journal of Physical Chemistry B. Uploaded with permission from the publisher. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z EPSRC EP/G009546/1 |
Depositing User: | Pure (York) |
Date Deposited: | 07 Oct 2015 13:48 |
Last Modified: | 21 Jan 2025 17:18 |
Published Version: | https://doi.org/10.1021/acs.jpcb.5b00686 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acs.jpcb.5b00686 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:90523 |