Leek, J, Lench, N, Maraj, B et al. (8 more authors) (1995) Prostate-specific membrane antigen: evidence for the existence of a second related human gene. British Journal of Cancer, 72 (3). pp. 583-588. ISSN 0007-0920
Abstract
Prostate-specific membrane antigen (PSM) is a glycoprotein recognised by the prostate-specific monoclonal antibody 7E11-C5, which was raised against the human prostatic carcinoma cell line LNCaP. A cDNA clone for PSM has been described. PSM is of clinical importance for a number of reasons. Radiolabelled antibody is being evaluated both as an imaging agent and as an immunotherapeutic in prostate cancer. Use of the PSM promoter has been advocated for gene therapy applications to drive prostate-specific gene expression. Although PSM is expressed in normal prostate as well as in primary and secondary prostatic carcinoma, different splice variants in malignant tissue afford the prospect of developing reverse transcription-polymerase chain reaction (RT-PCR)-based diagnostic screens for the presence of prostatic carcinoma cells in the circulation. We have undertaken characterisation of the gene for PSM in view of the protein's interesting characteristics. Unexpectedly, we have found that there are other sequences apparently related to PSM in the human genome and that PSM genomic clones map to two separate and distinct loci on human chromosome 11. Investigation of the function of putative PSM-related genes will be necessary to enable us to define fully the role of PSM itself in the development of prostatic carcinoma and in the clinical management of this malignancy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 1995 Stockton Press. This is article is distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License. |
Keywords: | prostate cancer; imaging: immunotherapy; cytogenetics; chromosome 11 |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Genetics (LIBACS) (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Translational Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Jul 2016 08:22 |
Last Modified: | 12 Jul 2016 08:22 |
Published Version: | http://dx.doi.org/10.1038/bjc.1995.377 |
Status: | Published |
Publisher: | Cancer Research UK |
Identification Number: | 10.1038/bjc.1995.377 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:89200 |