Ye, S orcid.org/0000-0001-5152-5753, Marston, G, McLaughlan, JR orcid.org/0000-0001-5795-4372 et al. (9 more authors) (2015) Engineering gold nanotubes with controlled length and near-infrared absorption for theranostic applications. Advanced Functional Materials, 25 (14). pp. 2117-2127. ISSN 1616-301X
Abstract
Important aspects in engineering gold nanoparticles for theranostic applications include the control of size, optical properties, cytotoxicity, biodistribution, and clearance. In this study, gold nanotubes with controlled length and tunable absorption in the near-infrared (NIR) region have been exploited for applications as photothermal conversion agents and in vivo photoacoustic imaging contrast agents. A length-controlled synthesis has been developed to fabricate gold nanotubes (NTs) with well-defined shape (i.e., inner void and open ends), high crystallinity, and tunable NIR surface plasmon resonance. A coating of poly(sodium 4-styrenesulfonate) (PSS) endows the nanotubes with colloidal stability and low cytotoxicity. The PSS-coated Au NTs have the following characteristics: i) cellular uptake by colorectal cancer cells and macrophage cells, ii) photothermal ablation of cancer cells using single wavelength pulse laser irradiation, iii) excellent in vivo photoacoustic signal generation capability and accumulation at the tumor site, iv) hepatobiliary clearance within 72 h postintravenous injection. These results demonstrate that these PSS-coated Au NTs have the ideal attributes to develop their potential as effective and safe in vivo imaging nanoprobes, photothermal conversion agents, and drug delivery vehicles. To the best of knowledge, this is the first in vitro and in vivo study of gold nanotubes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Ye, S, Marston, G, McLaughlan, JR, Sigle, DO, Ingram, N, Freear, S, Baumberg, JJ, Bushby, RJ, Markham, AF, Critchley, K, Coletta, PL and Evans, SD (2015) Engineering gold nanotubes with controlled length and near-infrared absorption for theranostic applications. Advanced Functional Materials, 25 (14). 2117 - 2127. ISSN 1616-301X, which has been published in final form at http://dx.doi.org/10.1002/adfm.201404358. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | gold nanotubes; photothermal cell ablation; photoacoustic imaging; surface plasmon resonance |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Electronic & Electrical Engineering (Leeds) > Robotics, Autonomous Systems & Sensing (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Molecular & Nanoscale Physics The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Translational Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Oct 2015 14:13 |
Last Modified: | 01 Mar 2019 17:11 |
Published Version: | http://dx.doi.org/10.1002/adfm.201404358 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/adfm.201404358 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:87036 |