Harris, E, Tiganescu, A, Tubeuf, S et al. (1 more author) (2015) The prediction and monitoring of toxicity associated with long-term systemic glucocorticoid therapy. Current Rheumatology Reports, 17 (6). 513. ISSN 1523-3774
Abstract
Glucocorticoids are often required for adequate control of inflammation in many serious inflammatory diseases; common indications for long-term treatment include polymyalgia rheumatica, giant cell arteritis, asthma and chronic obstructive pulmonary disease. Long-term glucocorticoid therapy is, however, associated with many adverse effects involving skin, gastro-intestinal, eye, skeletal muscle, bone, adrenal, cardio-metabolic and neuropsychiatric systems. This balance between benefits and risks of glucocorticoids is important for clinical practice and glucocorticoid-related adverse effects can significantly impair health-related quality of life. Understanding the nature and mechanisms of glucocorticoid-related adverse effects may inform how patients are monitored for toxicity and identify those groups, such as older people, that may need closer monitoring. For clinical trials in diseases commonly treated with glucocorticoids, standardised measurement of glucocorticoid-related adverse effects would facilitate future evidence synthesis and meta-analysis.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | Glucocorticoids; Adverse effects; Giant cell arteritis; Polymyalgia rheumatica |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Rheumatology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Health Economics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 18 May 2015 10:22 |
Last Modified: | 18 May 2015 10:22 |
Published Version: | http://dx.doi.org/10.1007/s11926-015-0513-4 |
Status: | Published |
Publisher: | Current Medicine Group |
Identification Number: | 10.1007/s11926-015-0513-4 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:86131 |