Tronci, G, Doyle, A, Russell, SJ et al. (1 more author) (2012) Structure-property-function relationships in triple helical collagen hydrogels. In: MRS Online Proceedings Library. 2012 MRS Fall Meeting & Exhibit- Biomimetic, Bio-inspired and Self-Assembled Materials for Engineered Surfaces and Applications, 25-30 Nov 2012, Boston, Massachusetts. Cambridge University Press , 145 - 150.
Abstract
In order to establish defined biomimetic systems, type I collagen was functionalised with 1,3-Phenylenediacetic acid (Ph) as aromatic, bifunctional segment. Following investigation on molecular organization and macroscopic properties, material functionalities, i.e. degradability and bioactivity, were addressed, aiming at elucidating the potential of this collagen system as mineralization template. Functionalised collagen hydrogels demonstrated a preserved triple helix conformation. Decreased swelling ratio and increased thermo-mechanical properties were observed in comparison to state-of-the-art carbodiimide (EDC)-crosslinked collagen controls. Ph-crosslinked samples displayed no optical damage and only a slight mass decrease (∼ 4 wt.-%) following 1-week incubation in simulated body fluid (SBF), while nearly 50 wt.-% degradation was observed in EDC-crosslinked collagen. SEM/EDS revealed amorphous mineral deposition, whereby increased calcium phosphate ratio was suggested in hydrogels with increased Ph content. This investigation provides valuable insights for the synthesis of triple helical collagen materials with enhanced macroscopic properties and controlled degradation. In light of these features, this system will be applied for the design of tissue-like scaffolds for mineralized tissue formation.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2012, Cambridge University Press. This is an author produced version of a paper published in MRS Online Proceedings Library. Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | biomaterial; biomimetic (chemical reaction); morphology |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Jun 2015 12:50 |
Last Modified: | 31 Jul 2015 04:45 |
Published Version: | http://dx.doi.org/10.1557/opl.2012.1653 |
Status: | Published |
Publisher: | Cambridge University Press |
Identification Number: | 10.1557/opl.2012.1653 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:85104 |