Bulman, SEL, Goswami, P, Tronci, G et al. (2 more authors) (2015) Investigation into the potential use of poly(vinyl alcohol)/methylglyoxal fibres as antibacterial wound dressings. Journal of Biomaterials Applications, 29 (8). 1193 - 1200. ISSN 0885-3282
Abstract
As problems of antibiotic resistance increase, a continuing need for effective bioactive wound dressings is anticipated for the treatment of infected chronic wounds. Naturally derived antibacterial agents, such as Manuka honey, consist of a mixture of compounds, more than one of which can influence antimicrobial potency. The non-peroxide bacteriostatic properties of Manuka honey have been previously linked to the presence of methylglyoxal. The incorporation of methylglyoxal as a functional antibacterial additive during fibre production was explored as a potential route for manufacturing wound dressing components. Synthetic methylglyoxal and poly(vinyl alcohol) were fabricated into webs of sub-micron fibres by means of electrostatic spinning of an aqueous spinning solution. Composite fabrics were also produced by direct deposition of the poly(vinyl alcohol)–methylglyoxal fibres onto a preformed spunbonded nonwoven substrate. Attenuated total reflectance fourier transform infrared and proton nuclear magnetic resonance spectroscopies confirmed the presence of methylglyoxal within the resulting fibre structure. The antibacterial activity of the fibres was studied using strains of Staphylococcus aureus and Escherichia coli. Strong antibacterial activity, as well as diffusion of methylglyoxal from the fibres was observed at a concentration of 1.55 mg/cm2.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) The Author(s) 2014. This is an author produced version of a paper published in Journal of Biomaterials Applications. Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | Polyvinyl alcohol; methylglyoxal; fibres; antimicrobial; wound dressing |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 Mar 2015 15:59 |
Last Modified: | 16 Jan 2018 06:17 |
Published Version: | http://dx.doi.org/10.1177/0885328214556159 |
Status: | Published |
Publisher: | SAGE Publications |
Identification Number: | 10.1177/0885328214556159 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:83833 |