Rizzi, L, Head, DA and Auer, S (2015) Universality in the morphology and mechanics of coarsening amyloid fibril networks. Physical Review Letters, 114 (7). 078102. ISSN 0031-9007
Abstract
Peptide hydrogels have important applications as biomaterials and in nanotechnology, but utilization often depends on their mechanical properties for which we currently have no predictive capability. Here we use a peptide model to simulate the formation of percolating amyloid fibril networks and couple these to the elastic network theory to determine their mechanical properties. We find that the time variation of network length scales can be collapsed onto master curves by using a time scaling function that depends on the peptide interaction anisotropy. The same scaling applies to network mechanics, revealing a nonmonotonic dependence of the shear modulus with time. Our structure-function relationship between the peptide building blocks, network morphology, and network mechanical properties can aid in the design of amyloid fibril networks with tailored mechanical properties.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | (c) American Physical Society. This is an author produced version of a paper published in Physical Review Letters. Uploaded in accordance with the publisher's self-archiving policy |
Keywords: | Amyloid fibril networks; mechanical properties; universality; coarsening |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) > Institute for Computational and Systems Science (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 Mar 2015 15:00 |
Last Modified: | 17 Jan 2018 04:31 |
Published Version: | http://dx.doi.org/10.1103/PhysRevLett.114.078102 |
Status: | Published |
Publisher: | American Physical Society |
Identification Number: | 10.1103/PhysRevLett.114.078102 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:83793 |