Tarsuslugil, SM, O'Hara, RM, Dunne, NJ et al. (4 more authors) (2014) Experimental and computational approach investigating burst fracture augmentation using PMMA and calcium phosphate cements. Annals of Biomedical Engineering, 42 (4). 751 - 762. ISSN 0090-6964
Abstract
The aim of the study was to use a computational and experimental approach to evaluate, compare and predict the ability of calcium phosphate (CaP) and poly (methyl methacrylate) (PMMA) augmentation cements to restore mechanical stability to traumatically fractured vertebrae, following a vertebroplasty procedure. Traumatic fractures (n = 17) were generated in a series of porcine vertebrae using a drop-weight method. The fractured vertebrae were imaged using μCT and tested under axial compression. Twelve of the fractured vertebrae were randomly selected to undergo a vertebroplasty procedure using either a PMMA (n = 6) or a CaP cement variation (n = 6). The specimens were imaged using μCT and re-tested. Finite element models of the fractured and augmented vertebrae were generated from the μCT data and used to compare the effect of fracture void fill with augmented specimen stiffness. Significant increases (p < 0.05) in failure load were found for both of the augmented specimen groups compared to the fractured group. The experimental and computational results indicated that neither the CaP cement nor PMMA cement could completely restore the vertebral mechanical behavior to the intact level. The effectiveness of the procedure appeared to be more influenced by the volume of fracture filled rather than by the mechanical properties of the cement itself.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2014 The Author(s). This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
Keywords: | Animals; Biomechanical Phenomena; Bone Cements; Calcium Phosphates; Finite Element Analysis; Polymethyl Methacrylate; Spinal Fractures; Spine; Swine; Vertebroplasty; X-Ray Microtomography; Biomedical Engineering; Biophysics and Biological Physics; Mechanics; Biochemistry, general |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Feb 2015 12:01 |
Last Modified: | 16 Jan 2018 09:27 |
Published Version: | http://dx.doi.org/10.1007/s10439-013-0959-3 |
Status: | Published |
Publisher: | Springer Verlag |
Identification Number: | 10.1007/s10439-013-0959-3 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:82359 |