Zhang, Y, Jiang, Y, Zhang, D et al. (2 more authors) (2015) Metastable zone width, crystal nucleation and growth kinetics measurement in anti-solvent crystallization of β-artemether in the mixture of ethanol and water. Chemical Engineering Research and Design, 95. pp. 187-194. ISSN 1744-3563
Abstract
The production of -Artemether, 3, 12-epoxy- 12h-pyrano (4, 3- j)- 1, 2- benzodioxepin, C16H26O5), an important active pharmaceutical ingredient for the treatment of malaria, uses crystallization as the purification step. This paper investigates the Metastable Zone Width (MSZW), nucleation and crystal growth kinetics of anti-solvent crystallization for-artemether in ethanol + water system where water is the anti-solvent. Using a turbidity probe, the effect of process variables on MSZW was investigated, including initial the mass ratio of the solute to solvent, temperature, introduction rate as well as introduction location of the anti-solvent. The prediction model for MSZW was calibrated and proved reliable for this system. For anti-solvent crystallization of -artemether in ethanol + water system, the chord length distribution data was collected using Focused Beam Reflectance Measurement, based on which the nucleation and crystal growth parameters were estimated using the method of moment. The crystal growth mechanism of -artemether was also studied using a hot stage and imaging system and was found to follow a layer-by-layer growth mechanism.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 Elsevier B.V. Uploaded in accordance with the publisher's self-archiving policy. NOTICE: this is the author’s version of a work that was accepted for publication in Chemical Engineering Research and Design. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Engineering Research and Design, 2014) DOI:10.1016/j.cherd.2014.10.018 |
Keywords: | β-Artemether; FBRM; Crystallization; Kinetics; Mathematical modelling; Thermodynamics |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) > Institute for Particle Science and Engineering (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Nov 2014 11:25 |
Last Modified: | 25 Feb 2016 16:27 |
Published Version: | http://dx.doi.org/10.1016/j.cherd.2014.10.018 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.cherd.2014.10.018 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:81366 |