Das, C, Noro, MG and Olmsted, PD (2014) Fast cholesterol flip-flop and lack of swelling in skin lipid multilayers. Soft Matter, 10 (37). 7346 - 7352. ISSN 1744-683X
Abstract
Atomistic simulations were performed on hydrated model lipid multilayers that are representative of the lipid matrix in the outer skin (stratum corneum). We find that cholesterol transfers easily between adjacent leaflets belonging to the same bilayer via fast orientational diffusion (tumbling) in the inter-leaflet disordered region, while at the same time there is a large free energy cost against swelling. This fast flip-flop may play an important role in accommodating the variety of curvatures that would be required in the three dimensional arrangement of the lipid multilayers in skin, and for enabling mechanical or hydration induced strains without large curvature elastic costs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2015, Royal Society of Chemistry. This is an author produced version of a paper published in Soft Matter. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mathematics (Leeds) > Applied Mathematics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Oct 2014 14:34 |
Last Modified: | 03 Nov 2017 04:35 |
Published Version: | http://dx.doi.org/10.1039/c4sm01161a |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Refereed: | Yes |
Identification Number: | 10.1039/c4sm01161a |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:81107 |