Riches, K, Warburton, P, O'Regan, DJ et al. (2 more authors) (2014) Type 2 diabetes impairs venous, but not arterial smooth muscle cell function: possible role of differential RhoA activity. Cardiovascular Revascularization Medicine, 15 (3). 141 - 148. ISSN 1878-0938
Abstract
Coronary heart disease is the leading cause of morbidity in patients with type 2 diabetes mellitus (T2DM), frequently resulting in a requirement for coronary revascularization using the internal mammary artery (IMA) or saphenous vein (SV). Patency rates of SV grafts are inferior to IMA and further impaired by T2DM whilst IMA patencies appear similar in both populations. Smooth muscle cells (SMC) play a pivotal role in graft integration; we therefore examined the phenotype and proliferative function of IMA- and SV-SMC isolated from non-diabetic (ND) patients or those diagnosed with T2DM.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014, Elsevier. This is an author produced version of a paper published in Cardiovascular Revascularization Medicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Cell phenotype; internal mammary artery; RhoA; saphenous vein; smooth muscle cell; type 2 diabetes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Cardiovascular Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jul 2014 10:46 |
Last Modified: | 25 Jul 2014 05:52 |
Published Version: | http://dx.doi.org/10.1016/j.carrev.2014.02.005 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.carrev.2014.02.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:79763 |