Head, DA, Ikebe, E, Nakamasu, A et al. (5 more authors) (2014) High-frequency affine mechanics and nonaffine relaxation in a model cytoskeleton. Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, 89 (4). 042711. ISSN 1539-3755
Abstract
The cytoskeleton is a network of crosslinked, semiflexible filaments, and it has been suggested that it has properties of a glassy state. Here we employ optical-trap-based microrheology to apply forces to a model cytoskeleton and measure the high-bandwidth response at an anterior point. Simulating the highly nonlinear and anisotropic stress-strain propagation assuming affinity, we found that theoretical predictions for the quasistatic response of semiflexible polymers are only realized at high frequencies inaccessible to conventional rheometers. We give a theoretical basis for determining the frequency when both affinity and quasistaticity are valid, and we discuss with experimental evidence that the relaxations at lower frequencies can be characterized by the experimentally obtained nonaffinity parameter.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2014, American Physical Society. Reproduced in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) > Institute for Computational and Systems Science (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Jun 2014 09:35 |
Last Modified: | 24 Jan 2018 06:25 |
Published Version: | http://dx.doi.org/10.1103/PhysRevE.89.042711 |
Status: | Published |
Publisher: | American Physical Society |
Identification Number: | 10.1103/PhysRevE.89.042711 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:79183 |