Grant, CA, Twigg, PC, Savage, MD et al. (3 more authors) (2013) Estimating the mechanical properties of retinal tissue using contact angle measurements of a spreading droplet. Langmuir: the ACS journal of surfaces and colloids, 29 (16). 5080 - 5084. ISSN 0743-7463
Abstract
When a drop of liquid is placed on the surface of a soft material, the surface deformation and the rate of spreading of the triple contact point is dependent on the mechanical properties of the substrate. This study seeks to use drop spreading behavior to infer the mechanical properties of soft biological materials. As an illustration of the value of this technique we have compared the spreading behavior of a liquid droplet on two viscoelastic, soft materials, namely, an elastomer and a low concentration agar gel. The ratio of the mechanical properties of these soft materials obtained in this way is confirmed by atomic force microscopy (AFM) nanoindentation. By comparing the spreading behavior of a liquid on the retina with that of the same liquid on each of two viscoelastic materials, we can then estimate the elastic moduli of the retina: an estimate that is extremely difficult to carry out using AFM.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Jun 2014 13:33 |
Last Modified: | 03 Nov 2016 03:33 |
Published Version: | http://dx.doi.org/10.1021/la400650t |
Status: | Published |
Publisher: | ACS |
Identification Number: | 10.1021/la400650t |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:79100 |