Aldridge, J., Young, C., Tiernan, J. et al. (12 more authors) (2026) A standardised approach to the pathological dissection and reporting of pelvic exenteration specimens: Recommendations from the UK Pelvic Exenteration Network (UKPEN). Colorectal Disease, 28 (4). e70433. ISSN: 1462-8910
Abstract
Aim Pelvic exenterations are complex operations associated with significant morbidity and resource implications. Resection is undertaken with curative intent, and achieving clear margins is paramount to successful oncological outcomes. Comprehensive pathological reporting is essential, yet there are no internationally agreed guidelines describing an optimal approach.
Methods This article presents a standardised approach to the pathological dissection and reporting of pelvic exenteration specimens, endorsed by the UK Pelvic Exenteration Network (UKPEN). This includes all relevant steps of the clinical pathway, from acknowledging the importance of pathology involvement in pre-operative radiological planning to post-operative correlation meetings. Key recommendations are exemplified with illustrative examples.
Conclusion Standardisation of pelvic exenteration pathology will contribute to optimal patient care, enhance multidisciplinary learning and service development, provide quality assurance and auditable standards and facilitate national and international research.
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | This is an author produced version of an article published in Colorectal Disease, made available under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | locally advanced rectal cancer, locally recurrent rectal cancer, pathological, pelvic exenteration, resection margin |
| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) |
| Funding Information: | Funder Grant number Yorkshire Cancer Research Account Ref: 2UOLEEDS L386-RA/2015/R2/003 Yorkshire Cancer Research Account Ref: 2UOLEEDS L394-RA/2015/R1/003 Cancer Research UK Supplier No: 138573 RRCOER-Jun24/100004 |
| Date Deposited: | 23 Feb 2026 11:55 |
| Last Modified: | 15 May 2026 15:01 |
| Status: | Published |
| Publisher: | Wiley |
| Identification Number: | 10.1111/codi.70433 |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:238253 |
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Filename: Manuscript_A standardised pathological approach to pelvic exenteration specimens.pdf
Licence: CC-BY 4.0

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