The Method of Fundamental Solutions For Optical Fluorescence Tomography

In this paper, the method of fundamental solutions (MFS) is first developed for solving direct problems in bi-layer materials in the biomedical field of optical fluorescence. The governing system of second-order linear partial differential equations (PDEs) for the emission and excitation fluences is transformed into a single fourth-order PDE with appropriate boundary and interface matching conditions. The MFS is subsequently further developed, in conjunction with a constrained minimization regularization procedure, to solve nonlinear inverse optical fluorescence tomography problems. Numerical results confirm the accuracy, stability and versatility of the proposed meshless technique.