DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Gimeno-Valiente, F., Castignani, C., Larose Cadieux, E. orcid.org/0000-0002-9320-8040 et al. (265 more authors) (2025) DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution. Nature Genetics, 57 (9). pp. 2226-2237. ISSN: 1061-4036

Abstract

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Item Type: Article
Authors/Creators:
  • Gimeno-Valiente, F.
  • Castignani, C.
  • Larose Cadieux, E. ORCID logo https://orcid.org/0000-0002-9320-8040
  • Mensah, N.E.
  • Liu, X.
  • Chen, K.
  • Chervova, O.
  • Karasaki, T. ORCID logo https://orcid.org/0000-0001-6863-2360
  • Weeden, C.E.
  • Richard, C.
  • Lai, S.
  • Martínez-Ruiz, C. ORCID logo https://orcid.org/0000-0002-4817-0565
  • Lim, E.L.
  • Frankell, A.M. ORCID logo https://orcid.org/0000-0002-0341-7878
  • Watkins, T.B.K.
  • Stavrou, G. ORCID logo https://orcid.org/0000-0002-8427-5233
  • Usaite, I.
  • Lu, W.-T. ORCID logo https://orcid.org/0000-0002-1405-4806
  • Marinelli, D. ORCID logo https://orcid.org/0000-0002-6002-363X
  • Saghafinia, S.
  • Wilson, G.A.
  • Dhami, P. ORCID logo https://orcid.org/0000-0002-5408-1833
  • Vaikkinen, H.
  • Steif, J.
  • Veeriah, S.
  • Hynds, R.E. ORCID logo https://orcid.org/0000-0002-2170-8791
  • Hirst, M.
  • Hiley, C.
  • Feber, A.
  • Deniz, Ö ORCID logo https://orcid.org/0000-0001-7268-1923
  • Jamal-Hanjani, M. ORCID logo https://orcid.org/0000-0003-1212-1259
  • McGranahan, N. ORCID logo https://orcid.org/0000-0001-9537-4045
  • Bentham, R.
  • Jones, T.P.
  • Black, J.R.M.
  • Dietzen, M.
  • Litovchenko, M.
  • Thol, K.
  • Bunkum, A.
  • Hessey, S.
  • Liu, W.K.
  • Birkbak, N.J.
  • Huebner, A.
  • Puttick, C.
  • Moore, D.A.
  • Biswas, D.
  • Grigoriadis, K.
  • Bakir, M.A.
  • Lucas, O.
  • Vendramin, R.
  • Ward, S.
  • Harries, S.
  • Zaccaria, S.
  • Zaidi, R.
  • Patruno, L.
  • Karagianni, D.
  • Quezada, S.A.
  • Bola, S.K.
  • Forster, M.D.
  • Lee, S.M.
  • Naceur-Lombardelli, C.
  • Thakkar, K.
  • Sivakumar, M.
  • Vanloo, S.
  • Toncheva, A.
  • Prymas, P.
  • Mussa, B.
  • Magala, M.
  • Keene, E.
  • Leung, M.M.
  • Kittel, J.
  • Haase, K.
  • Koh, K.
  • Scott, R.
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  • Rowan, A.
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  • Wong, Y.N.S.
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  • Monk, F.
  • Holding, J.W.
  • Choudhary, J.
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  • Gorman, P.
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  • Pisciella, M.C.
  • Bandula, S.
  • Nicod, J.
  • Dwornik, A.
  • Karamani, A.
  • Chain, B.
  • Pearce, D.R.
  • Mastrokalos, G.-T.
  • Lowe, H.L.
  • Reading, J.L.
  • Hartley, J.A.
  • Selvaraju, K.
  • Ensell, L.
  • Shah, M.
  • Pawlik, P.
  • Gamble, S.
  • Ung, S.K.A.
  • Spanswick, V.
  • Wu, Y.
  • Lester, J.F.
  • Dulloo, S.
  • Fennell, D.A.
  • Bajaj, A.
  • Nakas, A.
  • Sodha-Ramdeen, A.
  • Tufail, M.
  • Scotland, M.
  • Boyles, R.
  • Rathinam, S.
  • Wilson, C.
  • Matharu, G.
  • Shaw, J.A.
  • Boleti, E.
  • Cheyne, H.
  • Khalil, M.
  • Richardson, S.
  • Cruickshank, T.
  • Price, G.
  • Kerr, K.M.
  • French, J.
  • Gilbert, K.
  • Naidu, B.
  • Patel, A.J.
  • Middleton, G.
  • Osman, A.
  • Sangha, M.
  • Langman, G.
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  • Djearaman, M.
  • Leek, A.
  • Hodgkinson, J.D.
  • Totton, N.
  • Crosbie, P.
  • Fontaine, E.
  • Granato, F.
  • Novasio, J.
  • Rammohan, K.
  • Joseph, L.
  • Bishop, P.
  • Joshi, V.
  • Waplington, S.
  • Atkin, A.
  • Brown, K.D.
  • Carter, M.
  • Chaturvedi, A.
  • Oliveira, P.
  • Lindsay, C.R.
  • Blackhall, F.H.
  • Summers, Y.
  • Tugwood, J.
  • Dive, C.
  • Krebs, M.G.
  • Paiva-Correia, A.
  • Aerts, H.J.W.L.
  • Schwarz, R.F.
  • Kaufmann, T.L.
  • Szallasi, Z.
  • Diossy, M.
  • Salgado, R.
  • Kassiotis, G.
  • Noorani, I.
  • Grönroos, E.
  • Goldman, J.
  • Escudero, M.
  • Hobson, P.
  • Boeing, S.
  • Denner, T.
  • Barbè, V.
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  • Nye, E.
  • Stone, R.K.
  • Peggs, K.S.
  • Veiga, C.
  • Royle, G.
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  • Taylor, M.N.
  • Lawrence, D.
  • Patrini, D.
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  • Leslie, R.
  • Hacker, A.-M.
  • Smith, S.
  • Walker, A.
  • Grapa, A.
  • Zhang, H.
  • AbdulJabbar, K.
  • Pan, X.
  • Yuan, Y.
  • Chuter, D.
  • MacKenzie, M.
  • Chee, S.
  • Georg, P.
  • Alzetani, A.
  • Cave, J.
  • Lim, E.
  • Nicholson, A.G.
  • De Sousa, P.
  • Jordan, S.
  • Rice, A.
  • Raubenheimer, H.
  • Bhayani, H.
  • Ambrose, L.
  • Devaraj, A.
  • Chavan, H.
  • Begum, S.
  • Buderi, S.I.
  • Kaniu, D.
  • Malima, M.
  • Booth, S.
  • Fernandes, N.
  • Shah, P.
  • Proli, C.
  • Hewish, M.
  • Danson, S. ORCID logo https://orcid.org/0000-0002-3593-2890
  • Shackcloth, M.J.
  • Robinson, L.
  • Russell, P.
  • Blyth, K.G.
  • Kidd, A.
  • Dick, C.
  • Le Quesne, J.
  • Kirk, A.
  • Asif, M.
  • Bilancia, R.
  • Kostoulas, N.
  • Whiteley, J.
  • Thomas, M.
  • Beck, S. ORCID logo https://orcid.org/0000-0001-5290-2151
  • Demeulemeester, J. ORCID logo https://orcid.org/0000-0002-2660-2478
  • Tanić, M. ORCID logo https://orcid.org/0000-0003-3102-776X
  • Swanton, C. ORCID logo https://orcid.org/0000-0002-4299-3018
  • Van Loo, P. ORCID logo https://orcid.org/0000-0003-0292-1949
  • Kanu, N. ORCID logo https://orcid.org/0000-0001-7232-1952
Copyright, Publisher and Additional Information:

© The Author(s) 2025. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Keywords: Humans; DNA Methylation; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; CpG Islands; DNA Copy Number Variations; Gene Expression Regulation, Neoplastic; Epigenesis, Genetic; Evolution, Molecular
Dates:
  • Submitted: 1 October 2024
  • Accepted: 21 July 2025
  • Published (online): 10 September 2025
  • Published: September 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Date Deposited: 30 Oct 2025 15:20
Last Modified: 30 Oct 2025 15:20
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s41588-025-02307-x
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Open Archives Initiative ID (OAI ID):

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