Prediction of MGMT methylation status in glioblastoma patients based on radiomics feature extracted from intratumoral and peritumoral MRI imaging

Chen, W.-S., Fu, F.-X., Cai, Q.-L. et al. (4 more authors) (2025) Prediction of MGMT methylation status in glioblastoma patients based on radiomics feature extracted from intratumoral and peritumoral MRI imaging. Scientific Reports, 15 (1). 27533. ISSN: 2045-2322

Abstract

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Item Type: Article
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© The Author(s) 2025 . This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

Keywords: Glioblastoma; MGMT methylation; Radiomics; MRI imaging; Machine learning; Personalized treatment
Dates:
  • Submitted: 17 December 2024
  • Accepted: 23 June 2025
  • Published (online): 29 July 2025
  • Published: 29 July 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Funding Information:
Funder
Grant number
Alzheimer’s Research UK
ARUK-SRF2017B-1
National Institute for Health and Care Research
NIHR203321
Depositing User: Symplectic Sheffield
Date Deposited: 05 Aug 2025 10:19
Last Modified: 05 Aug 2025 10:19
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s41598-025-08608-9
Sustainable Development Goals:
  • Sustainable Development Goals: Goal 3: Good Health and Well-Being
Open Archives Initiative ID (OAI ID):

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