Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

Lee, Jimmy Tsz Hang, Barnett, Sam N, Roberts, Kenny et al. (26 more authors) (2025) Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19. Nature Communications. 1979. ISSN 2041-1723

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Lee, Jimmy Tsz Hang
  • Barnett, Sam N
  • Roberts, Kenny
  • Ashwin, Helen
  • Milross, Luke
  • Cho, Jae-Won
  • Huseynov, Alik
  • Woodhams, Benjamin
  • Aivazidis, Alexander
  • Li, Tong
  • Majo, Joaquim
  • Chaves, Patricia
  • Lee, Michael
  • Miranda, Antonio M A
  • Jablonska, Zuzanna
  • Arena, Vincenzo
  • Hanley, Brian
  • Osborn, Michael
  • Uhlmann, Virginie
  • Xu, Xiao-Ning
  • McLean, Gary R
  • Teichmann, Sarah A
  • Randi, Anna M
  • Filby, Andrew
  • Kaye, Paul M ORCID logo https://orcid.org/0000-0002-8796-4755
  • Fisher, Andrew J
  • Hemberg, Martin
  • Noseda, Michela
  • Bayraktar, Omer Ali
Copyright, Publisher and Additional Information:

© 2025. The Author(s).

Keywords: COVID-19/pathology,Humans,Single-Cell Analysis,Pulmonary Alveoli/pathology,Transcriptome,Plasminogen Activator Inhibitor 1/metabolism,SARS-CoV-2,Osteopontin/metabolism,Macrophages/metabolism,Lung/pathology,Gene Expression Profiling,Signal Transduction,Metallothionein/genetics,Male
Dates:
  • Accepted: 21 January 2025
  • Published: 10 March 2025
Institution: The University of York
Academic Units: The University of York > Faculty of Sciences (York) > Hull York Medical School (York)
Depositing User: Pure (York)
Date Deposited: 09 May 2025 09:30
Last Modified: 09 May 2025 23:08
Published Version: https://doi.org/10.1038/s41467-025-56473-x
Status: Published
Refereed: Yes
Identification Number: 10.1038/s41467-025-56473-x
Open Archives Initiative ID (OAI ID):

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Description: s41467-025-56473-x

Licence: CC-BY-NC-ND 2.5

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