Dhali, A. orcid.org/0000-0002-1794-2569, Kipkorir, V., Maity, R. orcid.org/0009-0003-5316-2329 et al. (14 more authors) (2025) Artificial intelligence–assisted capsule endoscopy versus conventional capsule endoscopy for detection of small bowel lesions: a systematic review and meta‐analysis. Journal of Gastroenterology and Hepatology. ISSN 0815-9319
Abstract
Background
Capsule endoscopy (CE) is a valuable tool used in the diagnosis of small intestinal lesions. The study aims to systematically review the literature and provide a meta-analysis of the diagnostic accuracy, specificity, sensitivity, and negative and positive predictive values of AI-assisted CE in the diagnosis of small bowel lesions in comparison to CE.
Methods
Literature searches were performed through PubMed, SCOPUS, and EMBASE to identify studies eligible for inclusion. All publications up to 24 November 2024 were included. Original articles (including observational studies and randomized control trials), systematic reviews, meta-analyses, and case series reporting outcomes on AI-assisted CE in the diagnosis of small bowel lesions were included. The extracted data were pooled, and a meta-analysis was performed for the appropriate variables, considering the clinical and methodological heterogeneity among the included studies. Comprehensive Meta-Analysis v4.0 (Biostat Inc.) was used for the analysis of the data.
Results
A total of 14 studies were included in the present study. The mean age of participants across the studies was 54.3 years (SD 17.7), with 55.4% men and 44.6% women. The pooled accuracy for conventional CE was 0.966 (95% CI: 0.925–0.988), whereas for AI-assisted CE, it was 0.9185 (95% CI: 0.9138–0.9233). Conventional CE exhibited a pooled sensitivity of 0.860 (95% CI: 0.786–0.934) compared with AI-assisted CE at 0.9239 (95% CI: 0.8648–0.9870). The positive predictive value for conventional CE was 0.982 (95% CI: 0.976–0.987), whereas AI-assisted CE had a PPV of 0.8928 (95% CI: 0.7554–0.999). The pooled specificity for conventional CE was 0.998 (95% CI: 0.996–0.999) compared with 0.5367 (95% CI: 0.5244–0.5492) for AI-assisted CE. Negative predictive values were higher in AI-assisted CE at 0.9425 (95% CI: 0.9389–0.9462) versus 0.760 (95% CI: 0.577–0.943) for conventional CE.
Conclusion
AI-assisted CE displays superior diagnostic accuracy, sensitivity, and positive predictive values albeit the lower pooled specificity in comparison with conventional CE. Its use would ensure accurate detection of small bowel lesions and further enhance their management.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 The Author(s). Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/ |
Keywords: | artificial intelligence; bowel; capsule endoscopy; diagnosis; small intestine |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Mar 2025 14:27 |
Last Modified: | 25 Mar 2025 14:27 |
Status: | Published online |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/jgh.16931 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:224784 |