Wall, P.A., Sajid, C.O.H., Mitchinson, K. et al. (1 more author) (2025) Poly(amino acid) Synthesis from 2,5‐Diketopiperazines for Acid‐Actuated Drug Release. Macromolecular Materials and Engineering. 2500091. ISSN 1438-7492
Abstract
Poly(amino acids) have enormous potential value as biomaterials owing to their inherent biocompatibility, chemical functionality, and biodegradability. However, current commercial poly(amino acid) use is somewhat limited due to production protocols that often include highly toxic phosgene in monomer synthesis. To circumvent this unfortunate predicament, the use of bio-renewable 2,5-diketopiperazines (2,5-DKPs) as cyclic monomers is proposed for poly(amino acid) synthesis. Amphiphilic block copolymers are produced by using poly(ethylene glycol) methyl ether (mPEG) as a macroinitiator, and pH-sensitive nanoparticles form capable of highly controlled, acid-actuated, doxorubicin release. This route to poly(amino acid) synthesis may facilitate the safe and economically viable use of key biodegradable polymers in both every day and high-value biomedical products, such as materials for stimuli-responsive drug delivery.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2025 The Author(s). Macromolecular Materials and Engineering published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | 2,5-diketopiperazine ring-opening polymerization, 2,5-diketopiperazines, biorenewable polymers, drug delivery poly(amino acids), polymer recycling |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Funding Information: | Funder Grant number Innovate UK - KTP fkaTechnology Strategy Board (KTP) 509151 BBSRC (Biotechnology & Biological Sciences Research Council) BB/X011631/1 Royal Society of Chemistry Not Known The Clothworkers' Company Not Known National Printing Bureau of Japan n/a Royal Society of Chemistry Not Known Innovate UK - KTP fkaTechnology Strategy Board (KTP) 10099124 |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Mar 2025 11:40 |
Last Modified: | 24 Mar 2025 12:00 |
Published Version: | https://onlinelibrary.wiley.com/doi/10.1002/mame.2... |
Status: | Published online |
Publisher: | Wiley |
Identification Number: | 10.1002/mame.202500091 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:224696 |