scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria

Morang’a, C.M., Drake, R.S., Miao, V.N. et al. (10 more authors) (2024) scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria. Experimental Biology and Medicine, 249. 10233. ISSN 1535-3702

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Morang’a, C.M.
  • Drake, R.S.
  • Miao, V.N.
  • Nyakoe, N.K.
  • Amuzu, D.S.Y.
  • Appiah, V.
  • Aniweh, Y.
  • Bediako, Y.
  • Bah, S.Y. ORCID logo https://orcid.org/0000-0002-0309-6509
  • Shalek, A.K.
  • Awandare, G.A.
  • Otto, T.D.
  • Amenga-Etego, L.
Copyright, Publisher and Additional Information:

© 2025 Morang’a, Drake, Miao, Nyakoe, Amuzu, Appiah, Aniweh, Bediako, Bah, Shalek, Awandare, Otto and Amenga-Etego. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/

Keywords: Plasmodium falciparum; TNF-α signaling via NFκB; cell-cell interactions; immune responses; monocytes; scRNA-Sequencing; uncomplicated malaria; Humans; Child; Tumor Necrosis Factor-alpha; Monocytes; Male; Child, Preschool; Female; Signal Transduction; Malaria, Falciparum; NF-kappa B; Infant; Interferons; Plasmodium falciparum; RNA-Seq; Adolescent; Single-Cell Gene Expression Analysis
Dates:
  • Published: 3 January 2024
  • Published (online): 3 January 2025
  • Accepted: 5 December 2024
  • Submitted: 10 May 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 07 Mar 2025 11:05
Last Modified: 07 Mar 2025 11:12
Status: Published
Publisher: Frontiers Media SA
Refereed: Yes
Identification Number: 10.3389/ebm.2024.10233
Related URLs:
Sustainable Development Goals:
  • Sustainable Development Goals: Goal 3: Good Health and Well-Being
Open Archives Initiative ID (OAI ID):

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