Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma

Black, J.R.M. orcid.org/0000-0001-5598-7752, Bartha, G., Abbott, C.W. et al. (277 more authors) (2025) Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma. Nature Medicine, 31 (1). pp. 70-76. ISSN 1078-8956

Abstract

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Item Type: Article
Authors/Creators:
  • Black, J.R.M. ORCID logo https://orcid.org/0000-0001-5598-7752
  • Bartha, G.
  • Abbott, C.W.
  • Boyle, S.M. ORCID logo https://orcid.org/0000-0002-4402-8449
  • Karasaki, T. ORCID logo https://orcid.org/0000-0001-6863-2360
  • Li, B. ORCID logo https://orcid.org/0000-0001-6729-219X
  • Chen, R. ORCID logo https://orcid.org/0000-0001-7789-0978
  • Harris, J.
  • Veeriah, S.
  • Colopi, M.
  • Bakir, M.A. ORCID logo https://orcid.org/0000-0002-0846-8332
  • Liu, W.K.
  • Lyle, J.
  • Navarro, F.C.P. ORCID logo https://orcid.org/0000-0002-5640-9070
  • Northcott, J.
  • Pyke, R.M.
  • Hill, M.S. ORCID logo https://orcid.org/0000-0003-0718-8934
  • Thol, K.
  • Huebner, A.
  • Bailey, C.
  • Colliver, E.C. ORCID logo https://orcid.org/0000-0002-1497-0740
  • Martínez-Ruiz, C. ORCID logo https://orcid.org/0000-0002-4817-0565
  • Grigoriadis, K. ORCID logo https://orcid.org/0000-0002-8435-0176
  • Pawlik, P.
  • Moore, D.A.
  • Marinelli, D. ORCID logo https://orcid.org/0000-0002-6002-363X
  • Shutkever, O.G.
  • Murphy, C. ORCID logo https://orcid.org/0000-0003-1356-959X
  • Sivakumar, M.
  • Lester, J.F.
  • Bajaj, A.
  • Nakas, A.
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  • Boyles, R.
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  • Wilson, C.
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  • Bishop, P.
  • Shah, R.
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  • Carter, M.
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  • Ng, K.W.
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  • Richards, J.
  • Lim, E.
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  • Booth, S.
  • Nicholson, A.G.
  • Fernandes, N.
  • Shah, P.
  • Proli, C.
  • Hewish, M.
  • Danson, S. ORCID logo https://orcid.org/0000-0002-3593-2890
  • Shackcloth, M.J.
  • Robinson, L.
  • Russell, P.
  • Blyth, K.G.
  • Kidd, A.
  • Dick, C.
  • Le Quesne, J.
  • Kirk, A.
  • Asif, M.
  • Bilancia, R.
  • Kostoulas, N.
  • Thomas, M.
  • Shaw, J.A.
  • Hackshaw, A. ORCID logo https://orcid.org/0000-0002-5570-5070
  • McGranahan, N. ORCID logo https://orcid.org/0000-0001-9537-4045
  • Jamal-Hanjani, M. ORCID logo https://orcid.org/0000-0003-1212-1259
  • Frankell, A.M. ORCID logo https://orcid.org/0000-0002-0341-7878
  • Chen, R.O. ORCID logo https://orcid.org/0000-0002-2842-4476
  • Swanton, C. ORCID logo https://orcid.org/0000-0002-4299-3018
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© The Author(s) 2025. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

Keywords: Humans; Circulating Tumor DNA; Adenocarcinoma of Lung; Lung Neoplasms; Female; Male; Neoplasm Staging; Middle Aged; Aged; Biomarkers, Tumor; Preoperative Period; Prognosis; Sensitivity and Specificity
Dates:
  • Published: January 2025
  • Published (online): 13 January 2025
  • Accepted: 29 July 2024
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Depositing User: Symplectic Sheffield
Date Deposited: 28 Feb 2025 12:34
Last Modified: 28 Feb 2025 12:34
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1038/s41591-024-03216-y
Related URLs:
Sustainable Development Goals:
  • Sustainable Development Goals: Goal 3: Good Health and Well-Being
Open Archives Initiative ID (OAI ID):

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