Brooker, C. orcid.org/0000-0002-3422-8797 and Tronci, G. orcid.org/0000-0002-9426-4220 (2024) Infection-responsivity of commercial dressings through halochromic drop-casting. In: AIP Conference Proceedings. Proceedings Of The 38th International Conference Of The Polymer Processing Society (PPS-38), 22-26 May 2023, St. Gallen, Switzerland. AIP Publishing , p. 160002.
Abstract
Infection control remains one of the most challenging tasks in wound care, due to growing antimicrobial resistance and ineffective infection diagnostic tools at the point-of-care. To integrate therapeutic wound dressings with wound monitoring capability at the point-of-care to enable informed clinical decision-making, we investigate the encapsulation of a halochromic dye, i.e. bromothymol blue (BTB), onto two commercial dressings, i.e. Aquacel® Extra™ and Promogran®, through a simple drop-casting method. Our concept leverages the infection-associated rise in wound pH, on the one hand, and BTB’s colour change capability in the pH range of healing (pH: 5-6) and infected wounds (pH > 7), on the other hand. BTB-encapsulated samples show a prompt colour switch (yellow/orange Æ blue) following 1-hour incubation at pH 8. The effect of swelling ratio, chemical composition and microstructure is then explored to draw relationships between colour change capability and dressing dye retention.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Feb 2025 17:19 |
Last Modified: | 06 Feb 2025 17:19 |
Status: | Published |
Publisher: | AIP Publishing |
Identification Number: | 10.1063/5.0204952 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:222863 |