Corrigan, J. orcid.org/0000-0002-5238-5577, Li, F., Dawson, N. et al. (4 more authors) (2024) An interaction-based mixing model for predicting porosity and tensile strength of directly compressed ternary blends of pharmaceutical powders. International Journal of Pharmaceutics, 664. 124587. ISSN 0378-5173
Abstract
Predicting the mechanical properties of powder mixtures without extensive experimentation is important for model driven design in solid dosage form manufacture. Here, a new binary interaction-based model is proposed for predicting the compressibility and compactability of directly compressed pharmaceutical powder mixtures based on the mixture composition. The model is validated using blends of MCC, lactose and paracetamol or ibuprofen. Both compressibility and compactability profiles are predicted well for a variety of blend compositions of ternary mixtures for the two formulations. The model performs well over a wide range of compositions for both blends and better than either an ideal mixing model or a ternary interaction model. A design of experiments which reduces the amount of API required for fitting the model parameters for a new formulation is proposed to reduce amount of API required. The design requires only three blends containing API. The model gives similar performance to the well-known Reynolds et al. model (2017) when trained using the same data sets. The binary interaction model approach is generalizable to other powder mixture properties. The model presented in this work is limited to curve-fitting of empirical compaction models for mixtures of common pharmaceutical powders and is not intended to provide guidance on the practical operating space (or design space) limits.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Compactability; Compressibility; Direct compression; Formulation design; Modeling; Tensile Strength; Powders; Tensile Strength; Ibuprofen; Acetaminophen; Lactose; Porosity; Cellulose; Chemistry, Pharmaceutical; Drug Compounding; Excipients; Models, Theoretical |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > School of Chemical, Materials and Biological Engineering The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Funding Information: | Funder Grant number INNOVATE UK TS/T011270/1 41299 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Feb 2025 10:07 |
Last Modified: | 05 Feb 2025 10:07 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.ijpharm.2024.124587 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:222347 |