Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons

Harvey, C., Nowak, A., Zhang, S. et al. (13 more authors) (2025) Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons. BMC Medical Genomics, 18. 10. ISSN 1755-8794

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Item Type: Article
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© 2025 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords: Amyotrophic lateral sclerosis (ALS); Biomarker; Cell-free DNA; DNA methylation; IPSC-derived motor neuron; Whole-genome bisulfite sequencing; Amyotrophic Lateral Sclerosis; Humans; Motor Neurons; Biomarkers; DNA Methylation; Cell-Free Nucleic Acids; Induced Pluripotent Stem Cells
Dates:
  • Published: 14 January 2025
  • Published (online): 14 January 2025
  • Accepted: 6 January 2025
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Funding Information:
Funder
Grant number
WELLCOME TRUST (THE)
216596/Z/19/Z
National Institute for Health and Care Research
IS-BRC-1215-20017
Depositing User: Symplectic Sheffield
Date Deposited: 21 Jan 2025 10:36
Last Modified: 21 Jan 2025 10:36
Published Version: https://doi.org/10.1186/s12920-025-02084-w
Status: Published
Publisher: Springer Science and Business Media LLC
Refereed: Yes
Identification Number: 10.1186/s12920-025-02084-w
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Sustainable Development Goals:
  • Sustainable Development Goals: Goal 3: Good Health and Well-Being
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