Dynamics of the blood plasma proteome during hyperacute HIV-1 infection

Abstract

The complex dynamics of protein expression in plasma during hyperacute HIV-1 infection and its relation to acute retroviral syndrome, viral control, and disease progression are largely unknown. Here, we quantify 1293 blood plasma proteins from 157 longitudinally linked plasma samples collected before, during, and after hyperacute HIV-1 infection of 54 participants from four sub-Saharan African countries. Six distinct longitudinal expression profiles are identified, of which four demonstrate a consistent decrease in protein levels following HIV-1 infection. Proteins involved in inflammatory responses, immune regulation, and cell motility are significantly altered during the transition from pre-infection to one month post-infection. Specifically, decreased ZYX and SCGB1A1 levels, and increased LILRA3 levels are associated with increased risk of acute retroviral syndrome; increased NAPA and RAN levels, and decreased ITIH4 levels with viral control; and increased HPN, PRKCB, and ITGB3 levels with increased risk of disease progression. Overall, this study provides insight into early host responses in hyperacute HIV-1 infection, and present potential biomarkers and mechanisms linked to HIV-1 disease progression and viral load.

Metadata

Item Type:	Article
Authors/Creators:	Nazziwa, J. https://orcid.org/0000-0001-9029-7976 Freyhult, E. Hong, M.-G. https://orcid.org/0000-0001-8603-8293 Johansson, E. https://orcid.org/0000-0002-4712-3687 Årman, F. Hare, J. Gounder, K. Rezeli, M. Mohanty, T. https://orcid.org/0000-0003-4593-9612 Kjellström, S. https://orcid.org/0000-0003-4646-5279 Kamali, A. Karita, E. Kilembe, W. Price, M.A. Kaleebu, P. Allen, S. Hunter, E. https://orcid.org/0000-0002-4273-8631 Ndung’u, T. Gilmour, J. Rowland-Jones, S.L. https://orcid.org/0000-0001-5788-6998 Sanders, E. https://orcid.org/0000-0002-1062-8921 Hassan, A.S. https://orcid.org/0000-0001-5296-4264 Esbjörnsson, J. https://orcid.org/0000-0002-3822-4953
Copyright, Publisher and Additional Information:	© The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Humans; HIV Infections; HIV-1; Male; Proteome; Adult; Female; Viral Load; Blood Proteins; Biomarkers; Disease Progression; Longitudinal Studies; Middle Aged
Dates:	Published: 5 December 2024 Published (online): 5 December 2024 Accepted: 19 November 2024 Submitted: 2 April 2024
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Medicine and Population Health
Depositing User:	Symplectic Sheffield
Date Deposited:	10 Jan 2025 09:23
Last Modified:	10 Jan 2025 09:23
Status:	Published
Publisher:	Springer Science and Business Media LLC
Refereed:	Yes
Identification Number:	10.1038/s41467-024-54848-0
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:221547

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Dynamics of the blood plasma proteome during hyperacute HIV-1 infection

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