Mottram, Jeremy Charles orcid.org/0000-0001-5574-3766 (2024) LeishGEM:genome-wide deletion mutant fitness and protein localisations in Leishmania. Trends in parasitology. pp. 675-678. ISSN 1471-4922
Abstract
LeishGEM is a genome-wide functional annotation community resource for Leishmania mexicana, where deletion mutant growth in vitro and in vivo is measured and protein localisation is determined by endogenous tagging and LOPIT-DC (localisation of organelle proteins by isotope tagging with differential centrifugation) spatial proteomics. Data are being made available pre-publication via http://leishgem.org which allows data-driven identification of the mechanisms for Leishmania parasitism.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved. |
Keywords: | Protozoan Proteins/genetics,Genome, Protozoan/genetics,Leishmania mexicana/genetics,Gene Deletion,Leishmania/genetics,Genetic Fitness,Proteomics |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 20 Dec 2024 15:10 |
Last Modified: | 21 Dec 2024 00:26 |
Published Version: | https://doi.org/10.1016/j.pt.2024.06.003 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.pt.2024.06.003 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:221081 |
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Description: LeishGEM: genome-wide deletion mutant fitness and protein localisations in Leishmania
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