Garzón-Alvarado, D.A., Duque-Daza, C.A., Vaca-González, J.J. et al. (5 more authors) (2024) Part II: A new perspective for modeling the bone remodeling process: Biology, mechanics, and pathologies. Journal of Theoretical Biology, 593. 111894. ISSN 0022-5193
Abstract
In this paper, we explore the effects of biological (pathological) and mechanical damage on bone tissue within a benchmark model. Using the Finite Element Methodology, we analyze and numerically test the model’s components, capabilities, and performance under physiologically and pathologically relevant conditions. Our findings demonstrate the model’s effectiveness in simulating bone remodeling processes and self-repair mechanisms for micro-damage induced by biological internal conditions and mechanical external ones within bone tissue. This article is the second part of a series, where the first part presented the mathematical model and the biological and physical significance of the terms used in a simplified benchmark model. It explored the bone remodeling model’s application, implementation, and results under physiological conditions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This is an author produced version of a an article published in the Journal of Theoretical Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Bone remodeling; Komarova’s model; Osteoclasts; Osteoblasts; Osteocytes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Engineering Thermofluids, Surfaces & Interfaces (iETSI) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Jul 2024 13:16 |
Last Modified: | 23 Oct 2024 13:43 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.jtbi.2024.111894 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:214669 |
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Filename: NewBoneRemodelingModel_V02__part_II___Copy_13_junio.pdf
Licence: CC-BY-NC-ND 4.0
