Atma, Y., Murray, B.S. orcid.org/0000-0002-6493-1547, Sadeghpour, A. orcid.org/0000-0002-0475-7858 et al. (1 more author) (2024) Encapsulation of short-chain bioactive peptides (BAPs) for gastrointestinal delivery: a review. Food & Function, 15 (8). pp. 3959-3979. ISSN 2042-6496
Abstract
The majority of known peptides with high bioactivity (BAPs) such as antihypertensive, antidiabetic, antioxidant, hypocholesterolemic, anti-inflammatory and antimicrobial actions, are short-chain sequences of less than ten amino acids. These short-chain BAPs of varying natural and synthetic origin must be bioaccessible to be capable of being adsorbed systemically upon oral administration to show their full range of bioactivity. However, in general, in vitro and in vivo studies have shown that gastrointestinal digestion reduces BAPs bioactivity unless they are protected from degradation by encapsulation. This review gives a critical analysis of short-chain BAP encapsulation and performance with regard to the oral delivery route. In particular, it focuses on short-chain BAPs with antihypertensive and antidiabetic activity and encapsulation methods via nanoparticles and microparticles. Also addressed are the different wall materials used to form these particles and their associated payloads and release kinetics, along with the current challenges and a perspective of the future applications of these systems.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2024. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY 3.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Gastrointestinal Tract; Animals; Humans; Peptides; Hypoglycemic Agents; Drug Delivery Systems; Administration, Oral; Drug Compounding; Digestion; Nanoparticles |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Colloids and Food Processing (Leeds) The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Jun 2024 10:58 |
Last Modified: | 04 Jun 2024 10:58 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/d3fo04195f |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:213038 |