Morrell, A.H., Warren, N.J. orcid.org/0000-0002-8298-1417 and Thornton, P.D. orcid.org/0000-0003-3876-1617 (2024) The Production of Polysarcosine‐Containing Nanoparticles by Ring‐Opening Polymerisation‐Induced Self‐Assembly. Macromolecular Rapid Communications, 45 (15). 2400103. ISSN 1022-1336
Abstract
N-carboxyanhydride ring-opening polymerization-induced self-assembly (NCA ROPISA) offers a convenient route for generating poly(amino acid)-based nanoparticles in a single step, crucially avoiding the need for post-polymerization self-assembly. Most examples of NCA ROPISA make use of a poly(ethylene glycol) (PEG) hydrophilic stabilizing block, however this non-biodegradable, oil-derived polymer may cause an immunological response in some individuals. Alternative water-soluble polymers are therefore highly sought. This work reports the synthesis of wholly poly(amino acid)-based nanoparticles, through the chain-extension of a polysarcosine macroinitiator with L-Phenylalanine-NCA (L-Phe-NCA) and Alanine-NCA (Ala-NCA), via aqueous NCA ROPISA. The resulting polymeric structures comprise of predominantly anisotropic, rod-like nanoparticles, with morphologies primarily influenced by the secondary structure of the hydrophobic poly(amino acid) that enables their formation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2024 The Authors. Macromolecular Rapid Communications published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | amino acids; aqueous ring‐opening polymerisation; nanoparticles; polymer morphology and secondary structure; polymerisation‐induced self‐assembly (PISA) |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) The University of Leeds > Faculty of Arts, Humanities and Cultures (Leeds) > School of Design (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Apr 2024 16:05 |
Last Modified: | 15 Oct 2024 13:02 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/marc.202400103 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:211850 |