Han, J., Gao, W. and Harrity, J.P.A. orcid.org/0000-0001-5038-5699 (2024) Pd-Catalyzed [4 + 1] annulation strategy to functionalized 4-methyleneproline derivatives. The Journal of Organic Chemistry, 89 (3). pp. 1552-1555. ISSN 0022-3263
Abstract
A Pd-catalyzed formal [4 + 1] cycloaddition reaction of sulfur ylides and in situ-generated Pd-stabilized zwitterions offers a convenient route to a series of functionalized proline derivatives. The utility of this method is demonstrated by a gram-scale synthesis and chemoselective functionalization of a proline-based derivative.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2024 The Authors. Published by American Chemical Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Functionalization; Organic compounds; Pyrrolidines; Reaction products; Sulfur |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Feb 2024 14:50 |
Last Modified: | 13 Feb 2024 14:50 |
Published Version: | http://dx.doi.org/10.1021/acs.joc.3c02178 |
Status: | Published |
Publisher: | American Chemical Society (ACS) |
Refereed: | Yes |
Identification Number: | 10.1021/acs.joc.3c02178 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:209052 |