Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis

Abstract

Human African Trypanosomiasis (HAT) is a parasitic disease originating in sub-Saharan Africa. There is limited information about the changes in the blood brain barrier (BBB) during this infection. This study is the first to apply diffusion weighted ASL (DWASL) to examine changes in BBB impairment. No significant changes in water exchange across the BBB were found during the infection, even when a loss of barrier integrity was seen using Contrast Enhanced MRI (Gd-DTPA) during the late stage of the disease. Furthermore, using multiple boli ASL (mbASL), changes in cerebral blood flow (CBF) were found during the course of infection. Overall, this study highlights the need for further study of the BBB during HAT infection to understand the complex mechanisms behind impairment.

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Item Type:	Article
Authors/Creators:	Paterson, S. https://orcid.org/0000-0001-8974-5022 Vallatos, A. Rodgers, J. Holmes, W.M.
Copyright, Publisher and Additional Information:	© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Blood-Brain Barrier; Animals; Humans; Mice; Trypanosomiasis, African; Disease Models, Animal; Gadolinium DTPA; Magnetic Resonance Imaging
Dates:	Published: 29 March 2023 Published (online): 29 May 2023 Accepted: 5 May 2023
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Medical and Biological Engineering (iMBE) (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	14 Jul 2023 14:13
Last Modified:	14 Jul 2023 14:13
Status:	Published
Publisher:	Springer
Identification Number:	10.1038/s41598-023-34665-z
Related URLs:	Author
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:201454

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Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis

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