Giblett, JP and Bulluck, H orcid.org/0000-0002-1985-1783 (2020) Cardioprotection for acute MI in light of the CONDI2/ERIC-PPCI trial: New targets needed. Interventional Cardiology: Reviews, Research, Resources, 15. ISSN 1756-1477
Abstract
Protection against ischaemia–reperfusion injury after revascularisation in acute myocardial infarction remains an enigma. Many targets have been identified, but after the failure of the recent Effect of Remote Ischaemic Conditioning on Clinical Outcomes in ST-elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention (CONDI2/ERIC-PPCI) trial to show translation to clinical benefit, there is still no pharmacological or mechanical strategy that has translated to clinical practice. This article addresses the results of the CONDI2/ ERIC-PPCI trial in the context of previous studies of ischaemic conditioning, and then considers the prospects for other potential targets of cardioprotection. Finally, the authors examine the pitfalls and challenges in trial design for future investigation of cardioprotective strategies. In particular, this article highlights the need for careful endpoint and patient selection, as well as the need to pay attention to the biology of cardioprotection during the study.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for noncommercial purposes, provided the original work is cited correctly. |
Keywords: | Cardioprotection; remote ischaemic conditioning; trial design; MI; glucagon-like peptide 1; ischaemia–reperfusion injury; cyclosporine A |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Nov 2023 13:47 |
Last Modified: | 28 Nov 2023 13:47 |
Status: | Published |
Identification Number: | 10.15420/icr.2020.01 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:199581 |
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Filename: Cardioprotection for Acute MI in Light of the CONDI2ERIC-PPCI Trial New Targets Needed.pdf
Licence: CC-BY 4.0