Plomin, Robert, Gidziela, Agnieszka, Malanchini, Margherita et al. (1 more author) (2022) Gene-environment interaction using polygenic scores:Do polygenic scores for psychopathology moderate predictions from environmental risk to behavior problems? Development and psychopathology. pp. 1816-1826. ISSN 1469-2198
Abstract
The DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for attention-deficit/hyperactivity disorder and neuroticism moderate associations between parent reports of their children's environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study. Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respectively, of the variance in externalizing behavior problems (hyperactivity/inattention and conduct problems) across ages 7, 9 and 12, with no clear developmental trends. G and E predictions of emotional symptoms and peer relationship problems were weaker. A quarter (12 of 48) of our tests of GxE were nominally significant (p =.05). Increasing the predictive power of G and E would enhance the search for GxE.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Funding Information: We gratefully acknowledge the ongoing contribution of the participants in the Twins Early Development Study (TEDS) and their families. TEDS has been supported by a program grant to R.P. from the UK Medical Research Council (MR/M021475/1 and previously G0901245), with additional support from the US National Institutes of Health (AG046938) and the European Commission (602768; 295366). This work was supported by a Nuffield Foundation award (EDO/44110) to S.v.S, who is a recipient of a British Academy Mid-Career Fellowship (MF21\210017). Publisher Copyright: © 2022 Cambridge University Press. All rights reserved. |
Keywords: | behavior problems,genotype-environment interaction,polygenic scores,twins |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Social Sciences (York) > Education (York) |
Depositing User: | Pure (York) |
Date Deposited: | 15 Mar 2023 14:30 |
Last Modified: | 08 Feb 2025 00:49 |
Published Version: | https://doi.org/10.1017/S0954579422000931 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1017/S0954579422000931 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:197411 |
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Description: gene-environment-interaction-using-polygenic-scores-do-polygenic-scores-for-psychopathology-moderate-predictions-from-environmental-risk-to-behavior-problems
Licence: CC-BY 2.5