Yang, Zhongzhen, Swanson, Christopher R.B. and Unsworth, William Paul orcid.org/0000-0002-9169-5156 (2022) A consecutive ring expansion strategy towards the macrocyclic core of the solomonamide natural products. Synlett. ISSN 0936-5214
Abstract
A synthetic strategy based on the application of three consecutive ring expansion reactions has been used in the synthesis of analogues of the macrocyclic core of the solomonamide natural products. Starting from a simple, readily available tetrahydrocarbazole, oxidative ring expansion is followed by two further 3-and 4-atom ring expansion reactions, enabling the insertion of amino acid-and hydroxyacid-derived linear fragments into 15-17-membered ring-enlarged macrocyclic products.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 Georg Thieme Verlag. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details |
Keywords: | Lactams,Lactones,Macrocycles,Medium-sized rings,Natural product analogues,Ring expansion,Solomonamides |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 11 Oct 2022 15:10 |
Last Modified: | 11 Jan 2025 00:09 |
Published Version: | https://doi.org/10.1055/a-1932-9717 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1055/a-1932-9717 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:191982 |
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Filename: Zhongzhen_Solomonamide_Synlett_paper_version_5_REVISION.docx
Description: Zhongzhen Solomonamide Synlett paper version 5 REVISION