Amabebe, E. orcid.org/0000-0002-3924-5270, Ogidi, H. and Anumba, D.O. orcid.org/0000-0003-2502-3033 (2022) Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer. Reproduction and Fertility, 3 (3). R177-R191.
Abstract
The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes the myometrial contraction of labour at term or preterm appears to share some common mechanisms with the occurrence, growth, invasion and metastasis of cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are pivotal to the complex extracellular tissue modulation that includes degradation, remodelling and exchange of ECM components, which contribute to homeostasis under normal physiological conditions such as cervical remodelling during pregnancy and puerperium. However, in cancer such as that of the uterine cervix, this extensive network of extracellular tissue modulation is altered leading to disrupted cell–cell and cell–basement membrane adhesion, abnormal tissue growth, neovascularization and metastasis that disrupt homeostasis. Cervical ECM remodelling during pregnancy and puerperium could be a physiological albeit benign neoplasm. In this review, we examined the pathophysiologic differences and similarities in the role of MMPs in cervical remodelling and cervical carcinoma.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | cervical remodelling; cervical carcinoma; matrix metalloproteinase; preterm birth; extracellular matrix; tissue inhibitors of metalloproteinases |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number National Institute for Health Research 17/63/26 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Oct 2022 10:09 |
Last Modified: | 18 Oct 2022 10:09 |
Status: | Published |
Publisher: | Bioscientifica |
Refereed: | Yes |
Identification Number: | 10.1530/raf-22-0015 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:191910 |