Kassab-Bachi, A orcid.org/0000-0001-7601-2532, Ravikumar, N orcid.org/0000-0003-0134-107X, Wilcox, RK et al. (2 more authors) (2023) Contribution of Shape Features to Intradiscal Pressure and Facets Contact Pressure in L4/L5 FSUs: An In-Silico Study. Annals of Biomedical Engineering, 51 (1). pp. 174-188. ISSN 0090-6964
Abstract
Finite element models (FEMs) of the spine commonly use a limited number of simplified geometries. Nevertheless, the geometric features of the spine are important in determining its FEM outcomes. The link between a spinal segment’s shape and its biomechanical response has been studied, but the co-variances of the shape features have been omitted. We used a principal component (PCA)-based statistical shape modelling (SSM) approach to investigate the contribution of shape features to the intradiscal pressure (IDP) and the facets contact pressure (FCP) in a cohort of synthetic L4/L5 functional spinal units under axial compression. We quantified the uncertainty in the FEM results, and the contribution of individual shape modes to these results. This parameterisation approach is able to capture the variability in the correlated anatomical features in a real population and sample plausible synthetic geometries. The first shape mode (ϕ1
) explained 22.6% of the shape variation in the subject-specific cohort used to train the SSM, and had the largest correlation with, and contribution to IDP (17%) and FCP (11%). The largest geometric variation in (ϕ1
) was in the annulus-nucleus ratio.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
Keywords: | Finite element models; Statistical shape models; Sensitivity analysis; Spine biomechanics; Virtual subjects |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) |
Funding Information: | Funder Grant number Royal Academy of Engineering LTRF2021\17115 Royal Academy of Engineering CiET1819\19 |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Sep 2022 09:07 |
Last Modified: | 01 Feb 2023 01:53 |
Status: | Published |
Publisher: | Springer Nature |
Identification Number: | 10.1007/s10439-022-03072-2 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:190896 |
Commentary/Response Threads
- Kassab-Bachi, A, Ravikumar, N, Wilcox, RK, Frangi, AF and Taylor, ZA Contribution of Shape Features to Intradiscal Pressure and Facets Contact Pressure in L4/L5 FSUs: An In-Silico Study. (deposited 13 Sep 2022 09:07) [Currently Displayed]