The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis

Guthertz, N orcid.org/0000-0001-7247-1176, van der Kant, R orcid.org/0000-0003-3639-9749, Martinez, RM orcid.org/0000-0002-7371-8051 et al. (7 more authors) (2022) The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proceedings of the National Academy of Sciences (PNAS), 119 (22). e2200468119. ISSN 0027-8424

Abstract

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Item Type: Article
Authors/Creators:
Copyright, Publisher and Additional Information:

© 2022 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

Keywords: Amyloid; Aggregation; Evolution
Dates:
  • Published: 31 May 2022
  • Published (online): 25 May 2022
  • Accepted: 15 April 2022
Institution: The University of Leeds
Academic Units: The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Structural Molecular Biology (Leeds)
The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Synthetic Biology (Leed)
Funding Information:
Funder
Grant number
Wellcome Trust
204963/Z/16/Z
BBSRC (Biotechnology & Biological Sciences Research Council)
BB/M012573/1
Wellcome Trust
094232/Z/10/Z
Wellcome Trust
094232/Z/10/Z
Depositing User: Symplectic Publications
Date Deposited: 04 May 2022 13:27
Last Modified: 15 Jan 2025 11:29
Status: Published
Publisher: National Academy of Sciences
Identification Number: 10.1073/pnas.2200468119
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