Browse by Academic Unit (A-Z)

A

Adamson, H, Ajayi, MO, Campbell, E orcid.org/0000-0001-9564-9408 et al. (10 more authors) (2019) Affimer–Enzyme–Inhibitor Switch Sensor for Rapid Wash-free Assays of Multimeric Proteins. ACS Sensors, 4 (11). pp. 3014-3022. ISSN 2379-3694

Adamson, H, Nicholl, A, Tiede, C orcid.org/0000-0003-0280-4005 et al. (9 more authors) (2019) Affimers as anti-idiotypic affinity reagents for pharmacokinetic analysis of biotherapeutics. BioTechniques, 67 (6). ISSN 0736-6205

B

Balforth, MR, Haigh, J orcid.org/0000-0002-9518-4003, Kumar, V et al. (6 more authors) (2021) Piggybacking on the Cholera Toxin: Identification of a CTB-binding Protein as an Approach for Targeted Delivery of Proteins to Motor Neurons. Bioconjugate Chemistry, 32 (10). pp. 2205-2212. ISSN 1043-1802

Bawazar, LA, McNally, CS, Empson, CJ orcid.org/0000-0002-4808-8561 et al. (8 more authors) (2016) Combinatorial microfluidic droplet engineering for biomimetic material synthesis. Science Advances, 2 (10). e1600567. ISSN 2375-2548

Bedford, R, Tiede, C orcid.org/0000-0003-0280-4005, Hughes, R et al. (4 more authors) (2017) Alternative reagents to antibodies in imaging applications. In: Biophysical Reviews. 19th IUPAB Congress, 16-20 Jul 2017, Edinburgh, UK. Springer , pp. 299-308.

Bonetta, R, Hunter, GJ, Trinh, CH orcid.org/0000-0002-5087-5011 et al. (6 more authors) (2021) Substitution of histidine 30 by asparagine in manganese superoxide dismutase alters biophysical properties and supports proliferation in a K562 leukemia cell line. European Biophysics Journal, 50 (3-4). pp. 571-585. ISSN 0175-7571

C

Campbell, E., Adamson, H., Luxton, T. et al. (4 more authors) (2024) Therapeutic drug monitoring of immunotherapies with novel Affimer–NanoBiT sensor construct. Sensors & Diagnostics.

Curd, AP orcid.org/0000-0002-3949-7523, Leng, J orcid.org/0000-0001-9790-162X, Hughes, RE orcid.org/0000-0001-6167-8286 et al. (13 more authors) (2021) Nanoscale pattern extraction from relative positions of sparse 3D localizations. Nano Letters: a journal dedicated to nanoscience and nanotechnology, 21 (3). pp. 1213-1220. ISSN 1530-6984

D

Daniels, AD, Campeotto, I, van der Kamp, MW et al. (7 more authors) (2014) Reaction Mechanism of N-Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis. ACS Chemical Biology, 9 (4). pp. 1025-1032. ISSN 1554-8929

Drulyte, I orcid.org/0000-0003-1117-7699, Obajdin, J, Trinh, CH et al. (4 more authors) (2019) Crystal structure of the putative cyclase IdmH from the indanomycin nonribosomal peptide synthase/polyketide synthase. IUCrJ, 6 (6). pp. 1120-1133. ISSN 2052-2525

G

Gaule, TG, Smith, MA, Tych, KM et al. (5 more authors) (2018) Oxygen Activation Switch in the Copper Amine Oxidase of Escherichia coli. Biochemistry, 57 (36). pp. 5301-5314. ISSN 0006-2960

Guthertz, N orcid.org/0000-0001-7247-1176, van der Kant, R orcid.org/0000-0003-3639-9749, Martinez, RM orcid.org/0000-0002-7371-8051 et al. (7 more authors) (2022) The effect of mutation on an aggregation-prone protein: An in vivo, in vitro, and in silico analysis. Proceedings of the National Academy of Sciences (PNAS), 119 (22). e2200468119. ISSN 0027-8424

H

Hegedüs, Z, Hóbor, F, Shoemark, DK et al. (6 more authors) (2021) Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation. Chemical Science. ISSN 2041-6520

Hesketh, E, Tiede, C orcid.org/0000-0003-0280-4005, Adamson, H et al. (8 more authors) (2019) Affimer reagents as tools in diagnosing plant virus diseases. Scientific Reports, 9. 7524. ISSN 2045-2322

Hughes, DJ, Tiede, C orcid.org/0000-0003-0280-4005, Penswick, N et al. (12 more authors) (2017) Generation of specific inhibitors of SUMO-1– and SUMO-2/3–mediated protein-protein interactions using Affimer (Adhiron) technology. Science Signaling, 10 (505). eaaj2005. ISSN 1945-0877

Hunter, T, Bonetta, R, Sacco, A et al. (8 more authors) (2018) A Single Mutation is Sufficient to Modify the Metal Selectivity and Specificity of a Eukaryotic Manganese Superoxide Dismutase to Encompass Iron. Chemistry - A European Journal, 24 (20). pp. 5303-5308. ISSN 0947-6539

K

Kearney, KJ, Pechlivani, N orcid.org/0000-0001-5041-5763, King, R et al. (13 more authors) (2019) Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot and reduce bleeding complications. Blood, 133 (11). pp. 1233-1244. ISSN 0006-4971

King, RJ, Schuett, K, Tiede, C orcid.org/0000-0003-0280-4005 et al. (10 more authors) (2020) Fibrinogen interaction with complement C3: a potential therapeutic target to reduce thrombosis risk. Haematologica. ISSN 0390-6078

Koutsoumpeli, E, Tiede, C orcid.org/0000-0003-0280-4005, Murray, J et al. (4 more authors) (2017) Antibody mimetics for the detection of small organic compounds using a quartz crystal microbalance. Analytical Chemistry, 89 (5). pp. 3051-3058. ISSN 0003-2700

Kyle, S, James, KAR and McPherson, MJ orcid.org/0000-0002-0719-6427 (2012) Recombinant production of the therapeutic peptide lunasin. Microbial Cell Factories, 11. 28.

L

Li, S orcid.org/0000-0001-5297-9079, Gong, X, Mc Nally, CS et al. (7 more authors) (2016) Rapid Preparation of Highly Reliable PDMS Double Emulsion Microfluidic Devices. RSC Advances, 6 (31). pp. 25927-25933.

Li, S orcid.org/0000-0001-5297-9079, Zeng, M orcid.org/0000-0002-8627-4146, Gaule, T et al. (2 more authors) (2017) Passive Picoinjection Enables Controlled Crystallization in a Droplet Microfluidic Device. Small, 13 (41). 1702154. ISSN 1613-6810

Lopata, A, Hughes, R orcid.org/0000-0001-6167-8286, Tiede, C orcid.org/0000-0003-0280-4005 et al. (5 more authors) (2018) Affimer proteins for F-actin: novel affinity reagents that label F-actin in live and fixed cells. Scientific Reports, 8. 6572. ISSN 2045-2322

M

Martin, HL, Bedford, R, Heseltine, SJ et al. (5 more authors) (2018) Non-immunoglobulin scaffold proteins: Precision tools for studying protein-protein interactions in cancer. New Biotechnology, 45. pp. 28-35. ISSN 1871-6784

Miles, JA orcid.org/0000-0001-8839-9201, Hobor, F, Trinh, C orcid.org/0000-0002-5087-5011 et al. (12 more authors) (2021) Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Noncanonical Structural Motifs. ChemBioChem, 22 (1). pp. 232-240. ISSN 1439-4227

P

Pechlivani, N. orcid.org/0000-0001-5041-5763, Alsayejh, B., Almutairi, M.K. et al. (10 more authors) (2025) Use of Affimer Technology for Inhibition of α2-antiplasmin and Enhancement of Fibrinolysis. Blood Advances, 9 (1). pp. 89-100. ISSN 2473-9537

Prakash, A, Parsons, SJ, Kyle, S et al. (1 more author) (2012) Recombinant production of self-assembling β-structured peptides using SUMO as a fusion partner. Microbial Cell Factories, 11. 92. ISSN 1475-2859

R

Robinson, JI orcid.org/0000-0001-5425-7520, Baxter, EW, Owen, RL et al. (13 more authors) (2018) Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action. Proceedings of the National Academy of Sciences, 115 (1). E72-E81. ISSN 0027-8424

Roper, B.W.R. orcid.org/0000-0002-9897-4254, Tiede, C. orcid.org/0000-0003-0280-4005, Abdul-Zani, I. orcid.org/0000-0001-6080-3866 et al. (11 more authors) (2023) “Affimer” synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation. Journal of Biological Chemistry, 299 (11). 105325. ISSN 0021-9258

Ross, JF, Wildsmith, GC, Johnson, M et al. (9 more authors) (2019) Directed Assembly of Homopentameric Cholera Toxin B‑Subunit Proteins into Higher-Order Structures Using Coiled-Coil Appendages. Journal of the American Chemical Society, 141 (13). pp. 5211-5219. ISSN 0002-7863

S

Sandrin Gauer, J orcid.org/0000-0002-0835-639X, Duval, C orcid.org/0000-0002-4870-6542, Xu, RG orcid.org/0000-0003-0774-112X et al. (6 more authors) (2023) Fibrin-glycoprotein VI interaction increases platelet procoagulant activity and impacts clot structure. Journal of Thrombosis and Haemostasis, 21 (3). pp. 667-681. ISSN 1538-7933

Schlichthaerle, T, Eklund, A, Schueder, F et al. (7 more authors) (2018) Site‐specific labeling of Affimers for DNA‐PAINT microscopy. Angewandte Chemie - International Edition, 57 (34). pp. 11060-11063. ISSN 1433-7851

Selvaraj, M, Yegambaram, K, Todd, EJAA orcid.org/0000-0003-0011-262X et al. (10 more authors) (2018) The structure of the human respiratory syncytial virus M2-1 protein bound to the interaction domain of the phosphoprotein P defines the orientation of the complex. mBio, 9 (6). e01554-18.

Shamsuddin, SH, Gibson, TD, Tomlinson, DC orcid.org/0000-0003-4134-7484 et al. (3 more authors) (2021) Reagentless Affimer- and antibody-based impedimetric biosensors for CEA-detection using a novel non-conducting polymer. Biosensors and Bioelectronics, 178. 113013. ISSN 0956-5663

Shamsuddin, SH, Jayne, DG orcid.org/0000-0002-8725-3283, Tomlinson, DC orcid.org/0000-0003-4134-7484 et al. (2 more authors) (2021) Selection and characterisation of Affimers specific for CEA recognition. Scientific Reports, 11 (1). 744. ISSN 2045-2322

Smith, MA, Pirrat, P, Pearson, AR et al. (6 more authors) (2010) Exploring the Roles of the Metal Ions in Escherichia coli Copper Amine Oxidase,. Biochemistry, 49 (6). pp. 1268-1280. ISSN 0006-2960

Srdanović, S, Wolter, M, Trinh, CH orcid.org/0000-0002-5087-5011 et al. (3 more authors) (2022) Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. The FEBS Journal, 289 (17). pp. 5341-5358. ISSN 1742-464X

Stevenson, SR, Kamisugi, Y orcid.org/0000-0002-5265-3658, Trinh, CH et al. (15 more authors) (2016) Genetic analysis of Physcomitrella patens identifies ABSCISIC ACID NON-RESPONSIVE, a regulator of ABA responses unique to basal land plants and required for desiccation tolerance. Plant Cell, 28 (6). pp. 1310-1327. ISSN 1040-4651

T

Tang, AA-S, Tiede, C orcid.org/0000-0003-0280-4005, Hughes, DJ et al. (2 more authors) (2017) Isolation of isoform-specific binding proteins (Affimers) by phage display using negative selection. Science Signaling, 10 (505). eaan0868. ISSN 1945-0877

Tanner, S, Ariza, A, Richard, CA et al. (12 more authors) (2014) Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. Proceedings of the National Academy of Sciences, 111 (4). pp. 1580-1585. ISSN 0027-8424

Thangsunan, P, Lal, N, Tiede, C et al. (8 more authors) (2021) Affimer-based impedimetric biosensors for fibroblast growth factor receptor 3 (FGFR3): a novel tool for detection and surveillance of recurrent bladder cancer. Sensors and Actuators B: Chemical, 326. 128829. ISSN 0925-4005

Tiede, C orcid.org/0000-0003-0280-4005, Bedford, R, Heseltine, SJ et al. (43 more authors) (2017) Affimer proteins are versatile and renewable affinity reagents. eLife, 6. e24903. ISSN 2050-084X

Tiede, C orcid.org/0000-0003-0280-4005, Tang, AA orcid.org/0000-0002-5216-5080, Deacon, SE et al. (8 more authors) (2014) Adhiron: a stable and versatile peptide display scaffold for molecular recognition applications. Protein Engineering, Design and Selection, 27 (5). pp. 145-155. ISSN 1741-0126

Timms, N, Windle, CL, Polyakova, A et al. (5 more authors) (2013) Structural Insights into the Recovery of Aldolase Activity in N -Acetylneuraminic Acid Lyase by Replacement of the Catalytically Active Lysine with γ-Thialysine by Using a Chemical Mutagenesis Strategy. ChemBioChem, 14 (4). pp. 474-481. ISSN 1439-4227

Troshin, PV, Postis, VLG orcid.org/0000-0001-9251-4567, Ashworth, D et al. (3 more authors) (2011) PIMS sequencing extension: a laboratory information management system for DNA sequencing facilities. BMC Research Notes, 4. 48. ISSN 1756-0500

Turner, LD, Trinh, CH orcid.org/0000-0002-5087-5011, Hubball, RA et al. (5 more authors) (2022) From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. Journal of Medicinal Chemistry, 65 (2). pp. 1481-1504. ISSN 0022-2623

U

Ullah, R, Shehzad, A, Shah, MA et al. (6 more authors) (2020) C-Terminal Domain of the Human Zinc Transporter hZnT8 Is Structurally Indistinguishable from Its Disease Risk Variant (R325W). International Journal of Molecular Sciences, 21 (3). 926. ISSN 1661-6596

V

Vella, M., Manfield, I.W. orcid.org/0000-0003-3765-0325, Seychell, B.C. et al. (6 more authors) (2025) Mutations in the N-domain of aryl hydrocarbon receptor interacting protein affect interactions with heat shock protein 90β and phosphodiesterase 4A5. Biochimie, 228. pp. 114-126. ISSN 0300-9084

W

Wang, W, Guo, Y orcid.org/0000-0003-4607-7356, Tiede, C orcid.org/0000-0003-0280-4005 et al. (8 more authors) (2017) Ultraefficient Cap-Exchange Protocol To Compact Biofunctional Quantum Dots for Sensitive Ratiometric Biosensing and Cell Imaging. ACS Applied Materials and Interfaces, 9 (18). pp. 15232-15244. ISSN 1944-8244

Wang, W, Kong, Y, Jiang, J et al. (8 more authors) (2020) Photon induced quantum yield regeneration of cap-exchanged CdSe/CdS quantum rods for ratiometric biosensing and cellular imaging. Nanoscale. ISSN 2040-3364

Windle, CL, Simmons, KJ orcid.org/0000-0003-4846-9097, Ault, JR orcid.org/0000-0002-5131-438X et al. (4 more authors) (2017) Extending enzyme molecular recognition with an expanded amino acid alphabet. Proceedings of the National Academy of Sciences, 114 (10). pp. 2610-2615. ISSN 1091-6490

X

Xie, C, Tiede, C orcid.org/0000-0003-0280-4005, Zhang, X et al. (6 more authors) (2017) Development of an Affimer-antibody combined immunological diagnosis kit for glypican-3. Scientific Reports, 7 (1). 9608. p. 9608. ISSN 2045-2322

Xu, R.-G. orcid.org/0000-0003-0774-112X, Cheah, L.T., Adams, L. et al. (9 more authors) (2021) Affimers modulate GPVI interactions with collagen/fibrinogen and GPVI-mediated platelet aggregation. In: 29th Congress of the International Society on Thrombosis and Haemostasis, 17-21 Jul 2021, Philadephia (USA), Virtual.

Xu, R.-G. orcid.org/0000-0003-0774-112X, Tiede, C. orcid.org/0000-0003-0280-4005, Calabrese, A.N. orcid.org/0000-0003-2437-7761 et al. (13 more authors) (2024) Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer. Blood Advances, 8 (15). pp. 3917-3928. ISSN 2473-9529

Y

Yuzugullu Karakus, Y, Goc, G, Balci, S et al. (4 more authors) (2018) Identification of the site of oxidase substrate binding in Scytalidium thermophilum catalase. Acta crystallographica. Section D, Structural biology, 74 (Pt 10). pp. 979-985. ISSN 2059-7983

Z

Zhurauski, P, Arya, SK, Jolly, P et al. (4 more authors) (2018) Sensitive and selective Affimer-functionalised interdigitated electrode-based capacitive biosensor for Her4 protein tumour biomarker detection. Biosensors and Bioelectronics, 108. pp. 1-8. ISSN 0956-5663

Á

Álvarez-Rodríguez, B, Tiede, C orcid.org/0000-0003-0280-4005, Hoste, ACR orcid.org/0000-0001-6724-6062 et al. (11 more authors) (2020) Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests. PLOS Neglected Tropical Diseases, 14 (6). e0008364. ISSN 1935-2727