Clarke, Paul Andrew orcid.org/0000-0003-3952-359X, Sosunovych, Bohdan and Brown, Alexander (2022) Amino Imidate-Catalyzed Asymmetric Michael Reactions of Ketones and Nitroalkenes. SynOpen. SO-2022-01-0005-OP.R1. pp. 67-74. ISSN 2509-9396
Abstract
The efficiency of an amino imidate organocatalyst was evaluated in the Michael reaction of ketones with nitroalkenes. tert-Butyl L-proline imidate was found to be a syn-selective catalyst generating products with moderate to good enantioselectivities, of up to 84% e.e. The best substrates were found to be cyclic ketones and -nitrostyrenes. The catalytic efficiency and enantioselectivity was enhanced by the addition of 10 mol% of benzoic acid.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 07 Feb 2022 10:50 |
Last Modified: | 24 Oct 2024 00:15 |
Published Version: | https://doi.org/10.1055/a-1761-4495 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1055/a-1761-4495 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:183332 |