Rowley, JV, Wall, P, Yu, H et al. (5 more authors) (2021) Triggered and Monitored Drug Release from Bifunctional Hybrid Nanocomposites. Polymer Chemistry. ISSN 1759-9954
Abstract
Polymer-coated carbon dot-containing calcium carbonate nanoparticles are reported as unique nanocomposites capable of encapsulating a chemotherapeutic drug and displaying afterglow behaviour. The poly(amino acid) polymeric component enhances nanoparticle dispersion and drug retention in aqueous solution, and can be designed to be cleavable to enable doxorubicin release under acidic conditions. The encapsulated carbon nanodots offer fluorescence and brief afterglow to the nanocomposites at neutral pH, which is lost when the nanocomposites encounter acidic (pH 5) solution. The loss of drug molecules, and fluorescence and phosphorescence provided by the carbon dots, in acidic solution ensures that the reported materials have potential promise as early-stage candidates as devices for monitored payload delivery to acidic environments.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Colour Science (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Dec 2021 14:42 |
Last Modified: | 25 Jun 2023 22:50 |
Status: | Published online |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/d1py01227d |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:181051 |