Howard, F. orcid.org/0000-0001-9899-3079 and Muthana, M. orcid.org/0000-0003-2497-8903 (2020) Designer nanocarriers for navigating the systemic delivery of oncolytic viruses. Nanomedicine, 15 (1). pp. 93-110. ISSN 1743-5889
Abstract
Nanotechnology is paving the way for new carrier systems designed to overcome the greatest challenges of oncolytic virotherapy; systemic administration and subsequent implications of immune responses and specific cell binding and entry. Systemic administration of oncolytic agents is vital for disseminated neoplasms, however transition of nanoparticles (NP) to virotherapy has yielded modest results. Their success relies on how they navigate the merry-go-round of often-contradictory phases of NP delivery: circulatory longevity, tissue permeation and cellular interaction, with many studies postulating design features optimal for each phase. This review discusses the optimal design of NPs for the transport of oncolytic viruses within these phases, to determine whether improved virotherapeutic efficacy lies in the pharmacokinetic/pharmacodynamics characteristics of the NP–oncolytic viruses complexes rather than manipulation of the virus and targeting ligands.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Future Science Group. This is an author-produced version of a paper subsequently published in Nanomedicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | immunotherapy; magnetic guidance; nanomedicine; nanoparticles; nanotargeting; oncolytic virotherapy |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Human Metabolism (Sheffield) The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > Department of Oncology (Sheffield) |
Funding Information: | Funder Grant number CANCER RESEARCH UK C25574/A24321 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Jul 2021 10:31 |
Last Modified: | 12 Jul 2021 16:15 |
Status: | Published |
Publisher: | Future Medicine Ltd |
Refereed: | Yes |
Identification Number: | 10.2217/nnm-2019-0323 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:176076 |