Zhang, Y., Kumar, P. orcid.org/0000-0002-9965-8691, Lv, S. et al. (4 more authors) (2021) Recent advances in 3D bioprinting of vascularized tissues. Materials & Design, 199. 109398. ISSN 0264-1275
Abstract
3D bioprinting is a technology that combines computing science, biology and material engineering. It has been extensively explored to fabricate 3D vascularized constructs for tissue engineering. This scalable, reproducible and highly precise fabrication technology offers great potential to achieve vascularization in printed tissues, which is an important milestone towards organ printing in the foreseeable future. A successful vascularized tissue integrates a range of hierarchical, perfusable channels within the mechanically supportive biomaterials. This review summarises the recent advances in the 3D bioprinting of vascularized tissues. Firstly, the common biomaterials used as bioinks for 3D bioprinting are introduced. While natural polymers are more suitable to mimic extracellular matrix resulting in effective cell growth, synthetic polymers offer tailorable mechanical properties and printability. Afterwards, the main 3D bioprinting techniques and their most recent practical applications in fabricating perfusable vascular networks are described. Furthermore, the future trends and prospects are also discussed.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | 3D bioprinting; Bioink; Tissue engineering; Vascularized tissue; Inkjet bioprinting; Extrusion-based bioprinting; Stereolithography; Laser-assisted bioprinting |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Chemical and Biological Engineering (Sheffield) |
Funding Information: | Funder Grant number ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL EP/N007174/1 ENGINEERING AND PHYSICAL SCIENCE RESEARCH COUNCIL EP/N023579/1 ROYAL SOCIETY RG160662 Engineering and Physical Sciences Research Council EP/N023579/1 Engineering and Physical Sciences Research Council EP/N007174/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 18 Jan 2021 17:16 |
Last Modified: | 22 Jan 2022 01:20 |
Status: | Published |
Publisher: | Elsevier BV |
Refereed: | Yes |
Identification Number: | 10.1016/j.matdes.2020.109398 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:169415 |