Southwell, James W, Black, Conor M and Duhme-Klair, Anne-Kathrin orcid.org/0000-0001-6214-2459 (2020) Experimental Methods for Evaluating the Bacterial Uptake of Trojan Horse Antibacterials. ChemMedChem. ISSN 1860-7187
Abstract
The field of antibacterial siderophore conjugates, referred to as Trojan Horse antibacterials, has received increasing attention in recent years, driven by the rise of antimicrobial resistance. Trojan Horse antibacterials offer an opportunity to exploit the specific pathways present in bacteria for active iron uptake, potentially allowing the drugs to bypass membrane-associated resistance mechanisms. Hence, the Trojan Horse approach might enable the redesigning of old antibiotics and the development of antibacterials that target specific pathogens. Critical parts of evaluating such Trojan Horse antibacterials and improving their design are the quantification of their bacterial uptake and the identification of the pathways by which this occurs. In this minireview, we highlight a selection of the biological and chemical methods used to study the uptake of Trojan Horse antibacterials, exemplified with case studies, some of which have led to drug candidates in clinical development or approved antibiotics.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Wiley‐VCH GmbH. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC EP/L024829/1 |
Depositing User: | Pure (York) |
Date Deposited: | 14 Dec 2020 16:50 |
Last Modified: | 04 Feb 2025 00:08 |
Published Version: | https://doi.org/10.1002/cmdc.202000806 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/cmdc.202000806 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:169022 |
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