Clarke, Aimee K., Rossi-Ashton, James A., Taylor, Richard J.K. orcid.org/0000-0002-5880-2490 et al. (1 more author) (2020) Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade. Tetrahedron. 131392. ISSN 0040-4020
Abstract
Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynone-tethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © Elsevier B. V., 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
Keywords: | Akuammiline alkaloids,Cascade reactions,Dearomatisation,Indole,Ynones |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC EP/R013748/1 |
Depositing User: | Pure (York) |
Date Deposited: | 28 Jul 2020 13:40 |
Last Modified: | 17 Dec 2024 00:16 |
Published Version: | https://doi.org/10.1016/j.tet.2020.131392 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.tet.2020.131392 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:163836 |
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Description: ©Tetrahedron C2 ynone racemic version 12 REVISION FINAL
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