Clarke, Aimee K., Rossi-Ashton, James A., Taylor, Richard J.K. orcid.org/0000-0002-5880-2490 et al. (1 more author) (2020) Synthesis of polycyclic scaffolds via a gold-catalysed dearomative cyclisation cascade. Tetrahedron. 131392. ISSN: 0040-4020
Abstract
Polycyclic scaffolds found in akuammiline alkaloid natural products can be synthesised from ynone-tethered indoles, via a gold(I)-catalysed dearomative cyclisation cascade sequence. The ynone starting materials are themselves made via a two-step modular synthesis from simple tryptamine and tryptophol derivatives.
Metadata
| Item Type: | Article |
|---|---|
| Authors/Creators: |
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| Copyright, Publisher and Additional Information: | © Elsevier B. V., 2020. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
| Keywords: | Akuammiline alkaloids,Cascade reactions,Dearomatisation,Indole,Ynones |
| Dates: |
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| Institution: | The University of York |
| Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
| Funding Information: | Funder Grant number EPSRC EP/R013748/1 |
| Depositing User: | Pure (York) |
| Date Deposited: | 28 Jul 2020 13:40 |
| Last Modified: | 17 Sep 2025 02:05 |
| Published Version: | https://doi.org/10.1016/j.tet.2020.131392 |
| Status: | Published |
| Refereed: | Yes |
| Identification Number: | 10.1016/j.tet.2020.131392 |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:163836 |
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Description: ©Tetrahedron C2 ynone racemic version 12 REVISION FINAL
Licence: CC-BY-NC-ND 2.5

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