Piras, Carmen Cristina orcid.org/0000-0002-7128-2979, Mahon, Clare Sarah and Smith, David Kelham orcid.org/0000-0002-9881-2714 (2020) Self-Assembled Supramolecular Hybrid Hydrogel Beads Loaded with Silver Nanoparticles for Antimicrobial Application. Chemistry : A European Journal. pp. 8452-8457. ISSN 1521-3765
Abstract
This paper reports the formation of silver (Ag) NPs within spatially-resolved two-component hydrogel beads that combine a low-molecular-weight gelator (LMWG) DBS-CONHNH2 and a polymer gelator (PG) calcium alginate. The AgNPs are formed via in situ reduction of Ag(I), with the resulting nanoparticle-loaded gels being characterised in detail. We tested the antibacterial activity of the nanocomposite gel beads against two drug-resistant bacterial strains, often associated with hospital-acquired infections: vancomycin-resistant Enterococcus faecium (VRE) and Pseudomonas aeruginosa (PA14), and the AgNP-loaded gels showed good antimicrobial properties against both types of bacteria. We suggest that the gel bead format of these AgNP-loaded hybrid hydrogels makes them promising versatile materials for potential applications in orthopaedics or wound healing.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 WILEY‐VCH Verlag GmbH & Co. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number EPSRC EP/P03361X/1 EUROPEAN COMMISSION 702927 |
Depositing User: | Pure (York) |
Date Deposited: | 16 Apr 2020 11:10 |
Last Modified: | 16 Oct 2024 16:33 |
Published Version: | https://doi.org/10.1002/chem.202001349 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1002/chem.202001349 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:159559 |
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