Clark, ER, Hemmings, K orcid.org/0000-0002-4967-6314, Greco, S et al. (3 more authors) (2020) Tribological Characteristics of Human Vascular Smooth Muscle Cells: The Implication of Disease State on Friction. Biotribology, 22. 100122.
Abstract
The aim of this study was to establish a simple tribological model to assess the frictional properties of non-diabetic (ND) and Type 2 diabetic (T2DM) patients with the view to better understand the interfacial processes off icing in-vivo during angioplasty. Human primary smooth muscle cell (SMC) monolayers from non-diabetic (ND) and Type 2 diabetic (T2DM) patients were isolated and cultured. The coefficient of friction of ND and T2DM SMC monolayers was measured using a micro-tribometer set-up at normal loads (Fn) of 0.4 and 0.8 mN. The coefficient of friction was dependent on load and disease state. The cycle average coefficient of friction of patient grouped SMCs was μ = 0.107 ± 0.03 and 0.22 ± 0.01 for ND and T2DM respectively. Within the ND group, the coefficient of friction was seen to be patient specific, with the coefficient of friction varying significantly from μ = 0.03 ± 0.03 to 0.185 ± 0.07. Results show that disease state will affect the frictional properties of SMCs. In turn the disease state may also influence the SMCs susceptibly to tribologically induced inflammation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020 Elsevier Ltd. This is an author produced version of a paper published in Biotribology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Friction; Cells; Smooth muscle cells; ISR; Diabetes |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Mechanical Engineering (Leeds) > Institute of Functional Surfaces (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Specialist Science Education Dept (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/P009662/1 Wellcome Trust 108113/Z/15/Z Royal Society RG160398 |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Mar 2020 14:51 |
Last Modified: | 26 Feb 2021 01:38 |
Status: | Published |
Publisher: | Elsevier BV |
Identification Number: | 10.1016/j.biotri.2020.100122 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:158680 |