Horner, K, Hopkins, M orcid.org/0000-0002-7655-0215, Finlayson, G orcid.org/0000-0002-5620-2256 et al. (2 more authors) (2020) Biomarkers of appetite: is there a potential role for metabolomics? Nutrition Research Reviews, 33 (2). pp. 271-286. ISSN 0954-4224
Abstract
Knowing the biological signals associated with appetite control is crucial for understanding the regulation of food intake. Biomarkers of appetite have been defined as physiological measures that relate to subjective appetite ratings, measured food intake, or both. Several metabolites including amino acids, lipids and glucose were proposed as key molecules associated with appetite control over 60 years ago, and along with bile acids are all among possible appetite biomarker candidates. Additional metabolites that have been associated with appetite include endocannabinoids, lactate, cortisol and β-hydroxybutyrate. However, although appetite is a complex integrative process, studies often investigated a limited number of markers in isolation. Metabolomics involves the study of small molecules or metabolites present in biological samples such as urine or blood, and may present a powerful approach to further the understanding of appetite control. Using multiple analytical techniques allows the characterisation of molecules, such as carbohydrates, lipids, amino acids, bile acids and fatty acids. Metabolomics has proven successful in identifying markers of consumption of certain foods and biomarkers implicated in several diseases. However, it has been under-exploited in appetite control or obesity. The aim of this narrative review is to (1) provide an overview of existing metabolites that have been identified in human biofluids and associated with appetite control; and (2) discuss the potential of metabolomics to deepen understanding of appetite control in humans.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Authors 2020. This is an author produced version of a paper published in Nutrition Research Reviews. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Amino acids; Appetite; Glucose; Lipids; Metabolites; Satiety |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Nutrition and Public Health (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Mar 2020 11:20 |
Last Modified: | 13 Jul 2022 14:34 |
Status: | Published |
Publisher: | Cambridge University Press (CUP) |
Identification Number: | 10.1017/s0954422420000062 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:158260 |